Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Division of Health Sciences, Graduate School of Medicine, Kyushu University, Fukuoka, Japan.
Clin Transplant. 2020 Dec;34(12):e14117. doi: 10.1111/ctr.14117. Epub 2020 Nov 20.
The contribution of physical activity (PA) to the prevention of metabolic abnormalities following liver transplantation (LT) has not been well documented. We aimed to assess PA in post-LT patients and to quantify its relationships with the development of postoperative metabolic abnormalities and health-related quality of life (HRQOL). We recruited 111 patients who had undergone LT ≥ 6 months previously. PA was measured by accelerometry, and HRQOL was evaluated using SF-8. PA was quantified as the number of steps per day, and the time spent performing moderate-to-vigorous PA and light PA per week. The prevalence of hypertension, diabetes, and dyslipidemia increased more than twofold following LT. The proportion of the participants with a sedentary lifestyle (<5000 steps/day) was 36%. Logistic regression analysis showed that postoperative hypertension and obesity were associated with preoperative body mass index and the number of steps taken (in 2000 steps/day increments). Preoperative diabetes was associated with obesity, and PA was associated with physical function-related HRQOL scores. Thus, increasing the number of steps taken per day has the potential to reduce hypertension and obesity, and PA could improve physical function-related HRQOL in patients following LT.
体力活动（PA）对肝移植（LT）后代谢异常的预防作用尚未得到充分证实。我们旨在评估 LT 后的患者的 PA，并量化其与术后代谢异常和健康相关生活质量（HRQOL）的发展之间的关系。我们招募了 111 名 LT 后至少 6 个月的患者。通过加速度计测量 PA，使用 SF-8 评估 HRQOL。PA 量化为每天的步数，以及每周进行中等到剧烈 PA 和轻度 PA 的时间。LT 后，高血压、糖尿病和血脂异常的患病率增加了两倍多。久坐不动的生活方式（<5000 步/天）的参与者比例为 36%。逻辑回归分析表明，术后高血压和肥胖与术前体重指数和所走步数（每 2000 步/天递增）有关。术前糖尿病与肥胖有关，PA 与与身体功能相关的 HRQOL 评分有关。因此，每天增加的步数可能有助于降低高血压和肥胖的风险，PA 可以改善 LT 后的患者与身体功能相关的 HRQOL。
