Storozhuk Oleksiy B, Seleznyova Iryna B, Storozhuk Larysa A, Dovgalyuk Tetyana V, Storozhuk Borys G, Platonova Tetyana N
NATIONAL PIROGOV MEMORIAL MEDICAL UNIVERSITY, VINNYTSIA, UKRAINE.
RESEARCH INSTITUTE OF REHABILITATION OF NATIONAL PIROGOV MEMORIAL MEDICAL UNIVERSITY, VINNYTSIA, UKRAINE.
Wiad Lek. 2020;73(8):1723-1725.
The aim: To study the status of pro- and anticoagulant components of hemostasis in patients with stage VD CKD depending on residual renal function.
Materials and methods: 88 patients with stage VD CKD were studied, 16 of them had preserved residual renal function (RRF). Hemostatic parameters - soluble fibrin, D-dimer and protein C - were determined in the patients.
Results: Significant increase in soluble fibrin and fibrinogen levels along with depressive reaction of D-dimer and protein C were found in patients with stage VD CKD having lost RRF. Preserved RRF in those patients had positive influence on hemostatic profile, decreasing the degree of hypercoagulation.
Conclusions: 1. In long term dialysis patients with stage VD CKD and lost RRF, significantly increased levels in soluble fibrin and fibrinogen along with decreased D-dimer concentration were found, being a key factor in the development of thrombotic complications. 2. There was significant decrease in protein C activity in patients with lost RRF. 3. Preserved RRF in patients with stage VD CKD had positive influence on hemostatic profile.
研究Ⅴ期慢性肾脏病（CKD）患者止血的促凝和抗凝成分状态与残余肾功能的关系。
对88例Ⅴ期CKD患者进行研究，其中16例患者保留了残余肾功能（RRF）。检测患者的止血参数——可溶性纤维蛋白、D-二聚体和蛋白C。
结果显示，失去RRF的Ⅴ期CKD患者可溶性纤维蛋白和纤维蛋白原水平显著升高，同时D-二聚体和蛋白C呈抑制反应。这些患者保留RRF对止血状态有积极影响，降低了高凝程度。
结论：1. 在长期透析的Ⅴ期CKD且失去RRF的患者中，可溶性纤维蛋白和纤维蛋白原水平显著升高，同时D-二聚体浓度降低，这是血栓并发症发生的关键因素。2. 失去RRF的患者蛋白C活性显著降低。3. Ⅴ期CKD患者保留RRF对止血状态有积极影响。
