Department of Respiratory Medicine, Japanese Red Cross Fukui Hospital, Japan.
Third department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Japan.
Intern Med. 2021 Mar 1;60(5):771-775. doi: 10.2169/internalmedicine.5134-20. Epub 2020 Oct 14.
Malignant pleural mesothelioma (MPM) is mostly observed in patients with a history of asbestos exposure. Although other causes are rare, there are several reports of MPM induced by therapeutic radiation, mainly in Europe and North America. However, no such case has been reported in Japan. We herein report a 50-year-old Japanese woman who developed MPM 25 years after thoracic radiation therapy for Hodgkin's lymphoma. The patient had no history of exposure to asbestos; therefore, her history of radiation therapy was considered to be the cause of MPM. Clinicians should consider secondary MPM in patients with a history of thoracic radiation therapy.
恶性胸膜间皮瘤（MPM）主要见于有石棉暴露史的患者。虽然其他病因罕见，但有几例报道称 MPM 是由放射性治疗引起的，主要在欧洲和北美。然而，在日本尚无此类病例报告。本文报告了一例 50 岁日本女性，在因霍奇金淋巴瘤接受胸部放射治疗 25 年后发展为 MPM。该患者无石棉暴露史；因此，她的放射治疗史被认为是 MPM 的病因。临床医生应考虑有胸部放射治疗史的患者发生继发性 MPM。
