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Estradiol modulates the pulsatile secretion of biologically active luteinizing hormone in man.雌二醇调节男性体内具有生物活性的促黄体生成素的脉冲式分泌。
J Clin Invest. 1987 Sep;80(3):631-8. doi: 10.1172/JCI113115.
2
Actions of estradiol on the pulsatile secretion of bioactive luteinizing hormone in man.雌二醇对人生物活性促黄体生成素脉冲式分泌的作用。
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Attenuated release of biologically active luteinizing hormone in healthy aging men.健康老年男性中生物活性促黄体生成素的缓释
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本文引用的文献

1
Metabolic clearance and production rates of human luteinizing hormone in pre- and postmenopausal women.绝经前和绝经后妇女人促黄体生成素的代谢清除率和产生率。
J Clin Invest. 1968 Jan;47(1):38-47. doi: 10.1172/JCI105713.
2
Modulation of serum and pituitary luteinizing hormone bioactivity by androgen in the rat.雄激素对大鼠血清及垂体促黄体生成素生物活性的调节作用
Endocrinology. 1980 Jun;106(6):1941-8. doi: 10.1210/endo-106-6-1941.
3
Metabolic clearance rates of luteinizing hormone in women during different phases of the menstrual cycle and while taking an oral contraceptive.女性在月经周期不同阶段以及服用口服避孕药期间促黄体生成素的代谢清除率。
J Clin Endocrinol Metab. 1982 Oct;55(4):654-9. doi: 10.1210/jcem-55-4-654.
4
Pulsatile pituitary gonadotropin secretion during maturation of the dominant follicle in monkeys: estrogen positive feedback enhances the biological activity of LH.
Endocrinology. 1981 Dec;109(6):2270-2. doi: 10.1210/endo-109-6-2270.
5
Interactions between 17 beta-estradiol and progesterone in the control of luteinizing hormone and follicle-stimulating hormone release in rat anterior pituitary cells in culture.17β-雌二醇与孕酮在体外培养的大鼠垂体前叶细胞中对促黄体生成素和促卵泡激素释放的调控作用
Endocrinology. 1981 Jan;108(1):52-7. doi: 10.1210/endo-108-1-52.
6
The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes.去卵巢母羊中促性腺激素释放激素（GnRH）与促黄体生成素（LH）分泌之间的时间关系。
Endocrinology. 1982 Nov;111(5):1737-9. doi: 10.1210/endo-111-5-1737.
7
Luteinizing hormone-releasing hormone release during the rat estrous cycle and after ovariectomy, as estimated with push-pull cannulae.用推挽式套管法估计大鼠发情周期及卵巢切除术后促黄体生成激素释放激素的释放情况。
Endocrinology. 1982 Nov;111(5):1439-48. doi: 10.1210/endo-111-5-1439.
8
Biologically active luteinizing hormone is secreted in episodic pulsations that vary in relation to stage of the menstrual cycle.具有生物活性的促黄体生成素以间歇性脉冲形式分泌，其分泌情况随月经周期阶段而变化。
J Clin Endocrinol Metab. 1984 Jun;58(6):1050-8. doi: 10.1210/jcem-58-6-1050.
9
Mode of secretion of bioactive luteinizing hormone in man.人生物活性促黄体生成素的分泌模式。
J Clin Endocrinol Metab. 1983 Nov;57(5):993-1000. doi: 10.1210/jcem-57-5-993.
10
Role of endogenous opiates in the expression of negative feedback actions of androgen and estrogen on pulsatile properties of luteinizing hormone secretion in man.内源性阿片肽在雄激素和雌激素对男性促黄体生成素分泌的脉冲特性的负反馈作用表达中的作用。
J Clin Invest. 1984 Jul;74(1):47-55. doi: 10.1172/JCI111417.

雌二醇调节男性体内具有生物活性的促黄体生成素的脉冲式分泌。

Estradiol modulates the pulsatile secretion of biologically active luteinizing hormone in man.

作者信息

Veldhuis J D, Dufau M L

出版信息

J Clin Invest. 1987 Sep;80(3):631-8. doi: 10.1172/JCI113115.

DOI:10.1172/JCI113115
PMID:3305575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC442284/
Abstract

We investigated the effects of estradiol on bioactive luteinizing hormone (LH) release in normal men using two complementary strategies: (i) steady state intravenous infusions of estradiol at its endogenous production rate, and (ii) oral administration of the antiestrogen, tamoxifen HCl. Immunoreactive and biologically active LH were monitored by radioimmunoassay and the rat interstitial cell testosterone bioassay, respectively. Estradiol infusions significantly suppressed mean plasma bioactive LH concentrations and decreased the bio/immuno LH ratio. Conversely, antiestrogen treatment enhanced spontaneous bioactive LH pulse frequency, increased bioactive LH pulse amplitude, and augmented plasma intrapulse and interpulse bio/immuno LH ratios. Low-dose pulsed injections of exogenous gonadotropin-releasing hormone (GnRH) also increased plasma bio/immuno LH ratios. However, tamoxifen attenuated the ability of exogenous GnRH to further enhance the bio/immuno LH ratio, which suggests that endogenous LH release was already maximally enriched in LH bioactivity during antiestrogen administration. We conclude that estradiol modulates the pulsatile secretion of LH molecules enriched in biological activity in man.

摘要

我们采用两种互补策略研究了雌二醇对正常男性生物活性促黄体生成素（LH）释放的影响：（i）以其内源生成速率静脉内稳态输注雌二醇，以及（ii）口服抗雌激素药物盐酸他莫昔芬。分别通过放射免疫测定法和大鼠间质细胞睾酮生物测定法监测免疫反应性LH和生物活性LH。输注雌二醇显著抑制了平均血浆生物活性LH浓度，并降低了生物活性LH与免疫反应性LH的比值。相反，抗雌激素治疗提高了自发性生物活性LH脉冲频率，增加了生物活性LH脉冲幅度，并提高了血浆脉冲内和脉冲间生物活性LH与免疫反应性LH的比值。低剂量脉冲注射外源性促性腺激素释放激素（GnRH）也提高了血浆生物活性LH与免疫反应性LH的比值。然而，他莫昔芬减弱了外源性GnRH进一步提高生物活性LH与免疫反应性LH比值的能力，这表明在抗雌激素给药期间，内源性LH释放中的LH生物活性已达到最大富集。我们得出结论，雌二醇调节男性体内富含生物活性的LH分子的脉冲式分泌。