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两头落空?1901-1950 年诺贝尔生理学或医学奖和化学奖提名的药理学家,重点介绍约翰·雅各布·阿贝尔(1857-1938)。

Between two stools? Pharmacologists nominated for Nobel prizes in "physiology or medicine" and "chemistry" 1901-1950 with a focus on John Jacob Abel (1857-1938).

机构信息

Faculty of Medicine, Department for the History, Philosophy, and Ethics of Medicine, Heinrich Heine University Dusseldorf, Moorenstr. 5, 40225, Dusseldorf, Germany.

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 2021 Mar;394(3):503-513. doi: 10.1007/s00210-020-01993-0. Epub 2020 Oct 15.

Abstract

Since the early stages of its academic professionalization, pharmacology has been an interdisciplinary field strongly influenced by the natural sciences. Using the Nobel Prize as a lens to study the history of pharmacology, this article analyzes nominations of pharmacologists for two Nobel Prize categories, namely "chemistry" and "physiology or medicine" from 1901 to 1950. Who were they? Why were they proposed, and what do the Nobel dossiers say about excellence in pharmacology and research trends? This paper highlights the evaluation of "shortlisted" candidates, i.e., those candidates who were of particular interest for the members of the Nobel Committee in physiology or medicine. We focus on the US scholar John Jacob Abel (1857-1938), repeatedly referred to as the "Founder of American Pharmacology." Nominated 17 times in both categories, Abel was praised by his nominators for both basic research as well as for his influential positions as editor and his work as chair at Johns Hopkins University. The Abel nominations were evaluated for the Nobel Committee in chemistry by the Swedish professor of chemistry and pharmaceutics Einar Hammarsten (1889-1968), particularly interested in Abel's work on hormones in the adrenal glands and in the pituitary gland. Eventually, Hammarsten did not view Abel's work prizeworthy, partly because other scholars had done-according to Hammarsten-more important discoveries in the same fields. In conclusion, analyses of Nobel Prize nominations help us to better understand various meanings of excellence in pharmacology during the twentieth century and beyond.

摘要

自学术专业化的早期阶段以来,药理学一直是一个深受自然科学影响的跨学科领域。本文以诺贝尔奖为视角,分析了 1901 年至 1950 年间药理学家在“化学”和“生理学或医学”两个诺贝尔奖项类别的提名情况。他们是谁?为什么被提名?诺贝尔档案中对药理学卓越性和研究趋势有何评价?本文重点介绍了“入围”候选人的评价,即那些特别引起诺贝尔生理学或医学委员会成员关注的候选人。我们关注的是美国学者约翰·雅各布·阿贝尔(John Jacob Abel,1857-1938 年),他曾在这两个奖项类别中被提名 17 次,被提名者称赞他在基础研究方面以及在担任编辑和约翰霍普金斯大学主席的有影响力的职位上都很出色。瑞典化学和药物学教授埃纳尔·哈马施滕(Einar Hammarsten,1889-1968 年)对阿贝尔在肾上腺和脑垂体激素方面的工作特别感兴趣,对他在化学领域的诺贝尔提名进行了评价。最终,哈马施滕认为阿贝尔的工作不值得获奖,部分原因是其他学者在同一领域做出了——按照哈马施滕的说法——更重要的发现。总之,对诺贝尔奖提名的分析有助于我们更好地理解 20 世纪及以后药理学卓越性的各种含义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c53/7892506/9176e54348f1/210_2020_1993_Fig1_HTML.jpg

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