Department of General Surgery, The 2nd Affiliated Hospital of Harbin Medical University, No. 148 BaoJian Road, Harbin 150086, China.
Department of Anesthesiology, The 2nd Affiliated Hospital of Harbin Medical University, No. 148 BaoJian Road, Harbin 150086, China.
Clin Chim Acta. 2020 Dec;511:255-259. doi: 10.1016/j.cca.2020.10.011. Epub 2020 Oct 13.
Long noncoding RNAs (lncRNAs) are a group of RNAs over 200 nucleotides in length involved in diverse processes in tumor cells including proliferation, invasion and apoptosis. Given these facts, it is hardly accidental that variations in the expression of some lncRNAs have been found to be closely related to carcinogenesis and tumor growth and metastasis. HOTAIRM1, first discovered as an important factor for granulocytic differentiation in NB4 promyelocytic leukemia, has been shown to be a salient cancer-related lncRNA abnormally expressed in a variety of tumors. In this review, we summarize current evidence on the critical role of HOTAIRM1 in human malignancy, its potential mechanism of action and future use in the development of effective therapeutics.
长链非编码 RNA（lncRNA）是一组长度超过 200 个核苷酸的 RNA，参与肿瘤细胞中的多种过程，包括增殖、侵袭和凋亡。鉴于这些事实，lncRNA 的表达变化与癌发生和肿瘤生长及转移密切相关，这绝非偶然。HOTAIRM1 最初被发现是 NB4 早幼粒细胞白血病中粒细胞分化的重要因素，现已证明它是一种在多种肿瘤中异常表达的重要癌相关 lncRNA。在这篇综述中，我们总结了 HOTAIRM1 在人类恶性肿瘤中的关键作用、其潜在作用机制以及在开发有效治疗方法中的未来应用的现有证据。
