Department of Oncology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, China.
Department of Pathophysiology, School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, Hubei, China.
Front Immunol. 2023 Feb 2;14:1067520. doi: 10.3389/fimmu.2023.1067520. eCollection 2023.
Lung tumours are widespread pathological conditions that attract much attention due to their high incidence of death. The immune system contributes to the progression of these diseases, especially non-small cell lung cancer, resulting in the fast evolution of immune-targeted therapy. Myeloid-derived suppressor cells (MDSCs) have been suggested to promote the progression of cancer in the lungs by suppressing the immune response through various mechanisms. Herein, we summarized the clinical studies on lung cancer related to MDSCs. However, it is noteworthy to mention the discovery of long non-coding RNAs (lncRNAs) that had different phenotypes and could regulate MDSCs in lung cancer. Therefore, by reviewing the different phenotypes of lncRNAs and their regulation on MDSCs, we summarized the lncRNAs' impact on the progression of lung tumours. Data highlight LncRNAs as anti-cancer agents. Hence, we aim to discuss their possibilities to inhibit tumour growth and trigger the development of immunosuppressive factors such as MDSCs in lung cancer through the regulation of lncRNAs. The ultimate purpose is to propose novel and efficient therapy methods for curing patients with lung tumours.
肺部肿瘤是一种广泛存在的病理状况，由于其高死亡率而备受关注。免疫系统在这些疾病的进展中起作用，特别是非小细胞肺癌，导致免疫靶向治疗的快速发展。髓系来源的抑制细胞（MDSCs）被认为通过多种机制抑制免疫反应来促进肺部癌症的进展。在此，我们总结了与 MDSCs 相关的肺癌的临床研究。然而，值得注意的是，长链非编码 RNA（lncRNA）的发现具有不同的表型，并能调节肺癌中的 MDSCs。因此，通过回顾不同表型的 lncRNA 及其对 MDSCs 的调节，我们总结了 lncRNA 对肺部肿瘤进展的影响。数据突出显示 lncRNA 作为抗癌剂。因此，我们旨在通过调节 lncRNA 来讨论它们抑制肿瘤生长和触发免疫抑制因子（如 MDSCs）发展的可能性，以治疗肺癌患者。最终目的是为治疗肺部肿瘤患者提出新的有效治疗方法。
