Department of Oral Pathology, Maulana Azad Institute of Dental Sciences, New Delhi, 110002, India.
J Oral Biosci. 2020 Dec;62(4):336-341. doi: 10.1016/j.job.2020.10.002. Epub 2020 Oct 12.
The aim of our study was to ascertain the true nature of ghost cells (GCs) by immunolocalization of cytokeratin (CK) 6, CK19, and amelogenin in calcifying odontogenic cysts (COCs) and dentinogenic ghost cell tumors (DGCTs) in an attempt to determine the nature of this unique cell.
A total of thirteen cases (six COCs and seven DGCTs) were examined immunohistochemically, in order to compare immunoreactivity for CK6, CK19, and amelogenin in odontogenic GCs.
Positive expression of amelogenin (92.3%) and CK6 (77%) was chiefly found in GCs. CK19 expression was observed in the cytoplasm of odontogenic epithelial cells of the lining epithelium. GCs were devoid of CK19 expression and were positive only on the cytoplasmic periphery.
In the current study, GCs showed accumulation of amelogenin and hard keratins in their cytoplasm during pathological transformation.
通过免疫组织化学定位细胞角蛋白 (CK) 6、CK19 和釉原蛋白，确定牙源性钙化囊肿 (COC) 和牙源性影细胞瘤 (DGCT) 中鬼影细胞 (GC) 的真实性质，试图确定这种独特细胞的性质。
共检测了 13 例（6 例 COC 和 7 例 DGCT），以比较牙源性 GC 中 CK6、CK19 和釉原蛋白的免疫反应性。
GC 中主要发现釉原蛋白 (92.3%) 和 CK6 (77%) 的阳性表达。CK19 表达见于衬里上皮的牙源性上皮细胞的细胞质中。GC 无 CK19 表达，仅在细胞质周边呈阳性。
在本研究中，GC 在病理转化过程中其细胞质中积累釉原蛋白和硬角蛋白。
