Department of Oral and Maxillofacial Surgery, Kindai University Nara Hospital, 1248-1 Otodacho, Ikoma, Nara, 630-0293, Japan.
Department of Diagnostic Pathology, Kindai University Nara Hospital, 1248-1 Otodacho, Ikoma, Nara, 630-0293, Japan.
J Med Case Rep. 2023 Mar 30;17(1):114. doi: 10.1186/s13256-023-03861-w.
Dentinogenic ghost cell tumor is a rare benign tumor that accounts for less than 3% of all cases and consists of the stellate reticulum, which is made up of enamel epithelioid and basaloid cells. Although DGCT is a benign tumor, the local infiltration of the odontogenic epithelium or recurrences have been reported, and its detailed pathology and treatments remain unclear.
This report describes the case of a 60-year-old Japanese male diagnosed with a maxillary dentinogenic ghost cell tumor. Images showed well-circumscribed, multilocular cystic lesions with a calcified substance in the interior. Marsupialization was performed along with biopsy to prevent the expansion of the lesion, and a partial maxillectomy was performed 2 years after the initial examination. Histopathological findings showed ameloblastomatous proliferation containing clusters of ghost cells and dentinoid materials, resulting in the diagnosis of dentinogenic ghost cell tumor. This article also reviews recently reported cases of dentinogenic ghost cell tumor.
It is important to perform marsupialization, proper resection, and postoperative follow-up because of possible recurrence.
牙源性影细胞瘤是一种罕见的良性肿瘤,占所有病例的比例不到 3%,由星状网状结构组成,由釉质上皮样细胞和基底样细胞组成。虽然 DGCT 是一种良性肿瘤,但有报道称其存在局部浸润性牙源性上皮或复发,其详细的病理学和治疗方法仍不清楚。
本报告描述了一例 60 岁日本男性被诊断为上颌牙源性影细胞瘤的病例。影像学显示边界清楚的多房囊性病变,内部有钙化物质。为了防止病变扩大,进行了袋形手术,并在初次检查后 2 年进行了部分上颌骨切除术。组织病理学检查显示有成群的影细胞和成牙本质物质的釉细胞瘤样增生,最终诊断为牙源性影细胞瘤。本文还回顾了最近报道的牙源性影细胞瘤病例。
由于可能复发,因此进行袋形手术、适当的切除和术后随访非常重要。