Takata T, Zhao M, Nikai H, Uchida T, Wang T
Department of Oral Pathology, Hiroshima University School of Dentistry, Japan.
Histochem J. 2000 Apr;32(4):223-9. doi: 10.1023/a:1004051017425.
The so-called ghost cell is a unique cell type occurring in a variety of odontogenic and non-odontogenic lesions. However, the true nature of ghost cells has not been determined. In the present study, we examined the immunoreactivity of ghost cells in calcifying odontogenic cysts and dermal calcifying epitheliomas, with antibodies against amelogenin, enamelin, sheath protein (sheathlin) and enamelysin, in an attempt to clarify the nature of this unique cell. The cytoplasm of ghost cells in calcifying odontogenic cysts demonstrated distinct immunolocalization of the enamel-related proteins, while similar in the calcifying epitheliomas of the skin showed a negative reaction. The results indicate that the ghost cells in calcifying odontogenic cysts, as opposed to ghost cells in dermal calcifying epitheliomas, contain enamel-related proteins in their cytoplasm accumulated during the process of pathological transformation.
所谓的影细胞是一种独特的细胞类型，出现在多种牙源性和非牙源性病变中。然而，影细胞的真正性质尚未确定。在本研究中，我们用抗釉原蛋白、釉蛋白、鞘蛋白（鞘素）和釉质溶解蛋白的抗体检测了钙化牙源性囊肿和皮肤钙化上皮瘤中影细胞的免疫反应性，试图阐明这种独特细胞的性质。钙化牙源性囊肿中影细胞的细胞质显示出与釉质相关蛋白明显的免疫定位，而皮肤钙化上皮瘤中的情况则显示为阴性反应。结果表明，与皮肤钙化上皮瘤中的影细胞不同，钙化牙源性囊肿中的影细胞在其细胞质中含有在病理转化过程中积累的与釉质相关的蛋白。
