双阴性 T 细胞和局灶节段性肾小球硬化的持续干扰素产生。
Persistent Interferon Production by Double Negative T Cells and Collapsing Focal Segmental Glomerulosclerosis.
机构信息
Division of Renal electrolyte and hypertension, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
Nephron. 2021;145(1):85-90. doi: 10.1159/000510759. Epub 2020 Oct 15.
Collapsing glomerulopathy has multiple associations, including viral infections, medications like bisphosphonates and interferon, autoimmune diseases, and genetic predisposition. We report a case of collapsing focal segmental glomerulosclerosis associated with persistently high levels of interferon gamma produced by T-cell receptor αβ (+), CD4- CD8- (double negative) T lymphocytes that progressed despite treatment and improvement of other cytokine levels. Double negative T cells are elevated and activated in autoimmune lymphoproliferative syndrome (ALPS). Production of elevated interferon gamma levels from double negative T cells in ALPS despite treatment provides insight to the pathophysiology of collapsing glomerulopathy, guiding future research for collapsing glomerulopathy.
局灶节段性肾小球硬化症与多种疾病相关，包括病毒感染、双膦酸盐和干扰素等药物、自身免疫性疾病和遗传易感性等。我们报告了一例与 T 细胞受体 αβ（+）、CD4-CD8-（双阴性）T 淋巴细胞持续产生高水平干扰素γ相关的局灶节段性肾小球硬化症，尽管进行了治疗，但其他细胞因子水平有所改善，病情仍在进展。双阴性 T 细胞在自身免疫性淋巴增生综合征（ALPS）中升高并被激活。尽管进行了治疗，ALPS 中的双阴性 T 细胞仍会产生高水平的干扰素γ，这为局灶节段性肾小球硬化症的病理生理学提供了新的见解，并为局灶节段性肾小球硬化症的未来研究提供了指导。
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