Bai Lu, Li Jie-Qiong, Li Ying, Li Xin, Li Jian, Bo Tao
Department of Neonatology, Third Xiangya Hospital, Central South University, Changsha 410011, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2020 Oct;22(10):1066-1072. doi: 10.7499/j.issn.1008-8830.2005046.
To study the value of quantitative electroencephalography (qEEG) in evaluating the effect of blood glucose on the brain function of preterm infants.
The preterm infants who were admitted to the Department of Neonatology, The Third Xiangya Hospital of Central South University, from January to December 2019 were enrolled. According to the level of blood glucose, they were divided into group 1 (blood glucose <4.95 mmol/L), group 2 (blood glucose 4.95 to <6.60 mmol/L), group 3 (blood glucose 6.60 to <8.55 mmol/L), and group 4 (blood glucose ≥8.55 mmol/L). The changes in qEEG parameters were compared between groups, and a correlation analysis was performed for blood glucose and qEEG parameters.
A total of 39 preterm infants were enrolled (84 blood glucose measurements). Compared with group 4, the other three groups had significant increases in the total spectral power of each brain region and the absolute power of each frequency band in the frontal and occipital regions (P<0.05). The total spectral power, δ/θ ratio, and (δ+θ)/(α+β) ratio of each brain region were negatively correlated with blood glucose level, while the relative power of θ frequency band was positively correlated with blood glucose level (P<0.05).
With the change in blood glucose, there are significant changes in the total spectral power of each brain region, the power of each frequency band, and the frequency spectrum composition on qEEG in preterm infants. qEEG may therefore become an important tool to monitor the effect of abnormal blood glucose on brain function in preterm infants.
探讨定量脑电图（qEEG）在评估血糖对早产儿脑功能影响中的价值。
选取2019年1月至12月在中南大学湘雅三医院新生儿科住院的早产儿。根据血糖水平分为1组（血糖<4.95 mmol/L）、2组（血糖4.95至<6.60 mmol/L）、3组（血糖6.60至<8.55 mmol/L）和4组（血糖≥8.55 mmol/L）。比较各组qEEG参数的变化，并对血糖与qEEG参数进行相关性分析。
共纳入39例早产儿（84次血糖测量）。与4组相比，其他三组各脑区的总谱功率以及额叶和枕叶各频段的绝对功率均显著增加（P<0.05）。各脑区的总谱功率、δ/θ比值和(δ+θ)/(α+β)比值与血糖水平呈负相关，而θ频段的相对功率与血糖水平呈正相关（P<0.05）。
随着血糖变化，早产儿qEEG各脑区的总谱功率、各频段功率及频谱组成均有显著变化。因此，qEEG可能成为监测异常血糖对早产儿脑功能影响的重要工具。
