Neonatal Intensive Care Unit, Máxima Medical Center, 5500 MB Veldhoven, The Netherlands.
Pediatr Res. 2011 Nov;70(5):529-34. doi: 10.1203/PDR.0b013e31822d748b.
Our study aimed at automated power spectral analysis of the EEG in preterm infants to identify changes of spectral measures with maturation. Weekly (10-20 montage) 4-h EEG recordings were performed in 18 preterm infants with GA <32 wk and normal neurological follow-up at 2 y, resulting in 79 recordings studied from 27(+4) to 36(+3) wk of postmenstrual age (PMA, GA + postnatal age). Automated spectral analysis was performed on 4-h EEG recordings. The frequency spectrum was divided in delta 1 (0.5-1 Hz), delta 2 (1-4 Hz), theta (4-8 Hz), alpha (8-13 Hz), and beta (13-30 Hz) band. Absolute and relative power of each frequency band and spectral edge frequency were calculated. Maturational changes in spectral measures were observed most clearly in the centrotemporal channels. With advancing PMA, absolute powers of delta 1 to 2 and theta decreased. With advancing PMA, relative power of delta 1 decreased and relative powers of alpha and beta increased, respectively. In conclusion, with maturation, spectral analysis of the EEG showed a significant shift from the lower to the higher frequencies. Computer analysis of EEG will allow an objective and reproducible analysis for long-term prognosis and/or stratification of clinical treatment.
我们的研究旨在通过自动功率谱分析早产儿的脑电图，以识别与成熟相关的频谱测量变化。在 18 名胎龄<32 周且 2 岁时神经发育正常的早产儿中进行每周（10-20 导联）4 小时脑电图记录，共获得 79 份记录，记录时间为胎龄后 27（+4）至 36（+3）周（GA+出生后年龄）。对 4 小时脑电图记录进行自动频谱分析。将频谱分为 delta1（0.5-1 Hz）、delta2（1-4 Hz）、theta（4-8 Hz）、alpha（8-13 Hz）和 beta（13-30 Hz）频段。计算每个频段的绝对和相对功率以及频谱边缘频率。在中央颞区通道中，频谱测量的成熟变化最为明显。随着 PMA 的增加，delta1 到 2 和 theta 的绝对功率降低。随着 PMA 的增加，delta1 的相对功率降低，alpha 和 beta 的相对功率分别增加。总之，脑电图的频谱分析显示，随着成熟，频谱从较低频率向较高频率显著转移。脑电图的计算机分析将允许对长期预后和/或临床治疗的分层进行客观和可重复的分析。
