Unicoc, department of orthodontics, Cl. 13 N No. 3N - 13, Cali, Colombia.
Universidad del Valle, department of orthodontics, Cl. 4b #36b37, Cali, Colombia.
Int Orthod. 2020 Dec;18(4):684-695. doi: 10.1016/j.ortho.2020.08.008. Epub 2020 Oct 12.
This systematic review aimed to establish an effective wavelength range for PhotoBioModulation (PBM) to relieve pain in orthodontic treatments.
The electronic literature search was carried out in the following databases: PubMed, ISI Web of Science, Scopus, and Cochrane. In the initial search, 255 papers were obtained. Deleting duplicates in the search left 180 items. One manually searched study was included for a total of 181 studies. According to PRISMA guidelines and a thorough analysis of their methodology, the final sample was composed of 13 RCTs. The final statistical analysis was performed in 11 studies. The statistical analysis sought to strengthen the collected data, determining the correlation coefficient (r) for the same time interval (24h) using a scale equivalent to the standard value (0-10cm). Aiming to reduce the effect of heterogeneity, the difference in cm between control group (GC) and experimental group (EG) averages was considered the outcome. This difference was correlated with the wavelength in nm, calculating the Pearson linear correlation coefficient, and calculating a logarithmic correlation.
The dispersion of the data obtained in the experimental groups at each given wavelength showed that the most significant number of studies were in the ranges of 780-830nm. The correlation between the wavelength and the difference between the control and experimental group averages, either linear (R2=0.0564, r=0.237) or logarithmic (R2=0.0688, r=0.262) was not significant (P>0.90). Therefore, pain reduction after 24h is not significantly dependent of wavelength.
The majority of RCTs related to pain relief in orthodontic treatment showed 780-830nm as the most effective photobiomodulation wavelength range for orthodontic pain relief. However, pain reduction after 24h is not significantly dependent of wavelength. The protocol was registered in PROSPERO (CRD42019119799).
本系统评价旨在确定光生物调节（PBM）缓解正畸治疗疼痛的有效波长范围。
电子文献检索在以下数据库中进行：PubMed、ISI Web of Science、Scopus 和 Cochrane。在最初的搜索中，获得了 255 篇论文。在搜索中删除重复项后，留下 180 项。一项手动搜索的研究被纳入，总共 181 项研究。根据 PRISMA 指南和对其方法学的深入分析，最终样本由 13 项 RCT 组成。最终的统计分析在 11 项研究中进行。统计分析旨在加强收集的数据，使用相当于标准值（0-10cm）的量表为同一时间间隔（24 小时）确定相关系数（r）。为了降低异质性的影响，考虑对照组（GC）和实验组（EG）平均值之间的 cm 差异作为结果。该差异与波长（nm）相关，计算 Pearson 线性相关系数，并计算对数相关。
在每个给定波长的实验组中获得的数据分散表明，数量最多的研究处于 780-830nm 范围内。波长与对照组和实验组平均值之间差异的线性（R2=0.0564，r=0.237）或对数（R2=0.0688，r=0.262）相关性不显著（P>0.90）。因此，24 小时后疼痛减轻与波长无关。
大多数与正畸治疗疼痛缓解相关的 RCT 表明，780-830nm 是缓解正畸疼痛最有效的光生物调节波长范围。然而，24 小时后疼痛减轻与波长无关。该方案已在 PROSPERO（CRD42019119799）中注册。
