Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Section of Ophthalmology, Department of Surgery, University of Calgary, Calgary, AB, Canada.
J Perinatol. 2020 Dec;40(12):1857-1862. doi: 10.1038/s41372-020-00852-3. Epub 2020 Oct 15.
To evaluate the effectiveness in reducing pain by giving oral sucrose and non-pharmacological comfort measures prior to topical administration of mydriatic eye drops on premature infants undergoing retinopathy of prematurity (ROP) screening eye exams in a neonatal intensive care unit (NICU).
A prospective quality improvement study was conducted in the NICU where infants were given oral sucrose prior to administration of mydriatic eye drops while a second person performed facilitated tucking and containment. Premature Infant Pain Profile (PIPP) scores were recorded during eye drop administration and compared to a group that did not receive any comfort measures.
Sixty-eight infants were enrolled. Mean PIPP scores increased an average of 1.5 (SD = 1.5) during administration of mydriatic drops without comfort measures compared to 0.6 (SD = 0.8) when comfort measures were used. This difference was statistically significant (p < 0.001).
Oral sucrose and simple comfort measures can be effective in reducing pain associated with mydriatic eye drops.
评估在新生儿重症监护病房(NICU)对早产儿进行早产儿视网膜病变(ROP)筛查性眼部检查时,在给予散瞳滴眼剂之前给予口服蔗糖和非药物性舒适措施,以减轻疼痛的效果。
在 NICU 中进行了一项前瞻性质量改进研究,在给予散瞳滴眼剂之前,婴儿先给予口服蔗糖,同时第二个人进行协助包裹和固定。在给予散瞳滴眼剂期间记录早产儿疼痛状况评分(PIPP),并与未接受任何舒适措施的组进行比较。
共纳入 68 名婴儿。与未使用任何舒适措施时 PIPP 评分平均增加 1.5(SD=1.5)相比,使用舒适措施时 PIPP 评分平均增加 0.6(SD=0.8)。这一差异具有统计学意义(p<0.001)。
口服蔗糖和简单的舒适措施可有效减轻散瞳滴眼相关疼痛。