Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Genet Med. 2021 Mar;23(3):576-580. doi: 10.1038/s41436-020-01004-w. Epub 2020 Oct 16.
Rare genetic conditions like Down syndrome (DS) are historically understudied. Infection is a leading cause of mortality in DS, along with cardiac anomalies. Currently, it is unknown how the COVID-19 pandemic affects individuals with DS. Herein, we report an analysis of individuals with DS who were hospitalized with COVID-19 in New York, New York, USA.
In this retrospective, dual-center study of 7246 patients hospitalized with COVID-19, we analyzed all patients with DS admitted in the Mount Sinai Health System and Columbia University Irving Medical Center. We assessed hospitalization rates, clinical characteristics, and outcomes.
We identified 12 patients with DS. Hospitalized individuals with DS are on average ten years younger than patients without DS. Patients with DS have more severe disease than controls, particularly an increased incidence of sepsis and mechanical ventilation.
We demonstrate that individuals with DS who are hospitalized with COVID-19 are younger than their non-DS counterparts, and that they have more severe disease than age-matched controls. We conclude that particular care should be considered for both the prevention and treatment of COVID-19 in these patients.
唐氏综合征（DS）等罕见遗传疾病在历史上研究较少。感染是 DS 患者死亡的主要原因之一，还有心脏异常。目前，尚不清楚 COVID-19 大流行如何影响 DS 患者。在此，我们报告了美国纽约市西奈山卫生系统和哥伦比亚大学欧文医学中心因 COVID-19 住院的 DS 患者的分析。
在这项针对 7246 例 COVID-19 住院患者的回顾性、双中心研究中，我们分析了西奈山卫生系统和哥伦比亚大学欧文医学中心收治的所有 DS 患者。我们评估了住院率、临床特征和结局。
我们确定了 12 例 DS 患者。与非 DS 患者相比，住院的 DS 患者平均年轻十岁。DS 患者的疾病比对照组更严重，尤其是败血症和机械通气的发生率更高。
我们表明，因 COVID-19 住院的 DS 患者比非 DS 患者年轻，且与年龄匹配的对照组相比，疾病更严重。我们的结论是，应特别考虑这些患者 COVID-19 的预防和治疗。
