Burn & Wound Healing Research Center, Department of Microbiology, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Anesthesiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Neurol Sci. 2021 May;42(5):1649-1652. doi: 10.1007/s10072-021-05091-8. Epub 2021 Feb 1.
The aim of the current study was to determine whether COVID-19 is associated with a different presenting clinical picture or a more severe course of illness in people with Down syndrome (DS).
All consecutive patients who were admitted at healthcare facilities anywhere in Fars province (located in the south of Iran with a population of 4,851,000 people) from 19 February 2020 to 20 November 2020 were included. For every patient with DS, three age- and sex-matched patients with COVID-19 and without any underlying medical conditions were selected as controls.
During the study period, 37,968 patients were hospitalized with a diagnosis of COVID-19. Eighteen patients had DS. Patients with DS were significantly more likely to be intubated [7 patients (39%)] compared with those without DS [3 patients (6%)]; p = 0.002. Patients with DS significantly more often died of COVID-19 compared with the controls [8 (44.4%) vs. 1 (1.9%); odds ratio: 24.37; 95% confidence interval 2.39-247.94; p = 0.007].
Patients with DS are among the high-risk populations with respect to severe COVID-19 and should receive the vaccine as soon as possible. Furthermore, they should receive more intensive care if they get hospitalized with the illness.
本研究旨在确定 COVID-19 是否与唐氏综合征（DS）患者的临床表现不同或疾病更严重。
本研究纳入了 2020 年 2 月 19 日至 2020 年 11 月 20 日期间在伊朗南部法尔斯省（拥有 485.1 万人口）任何医疗机构住院的所有连续患者。对于每一位患有 DS 的患者，选择了三位年龄和性别相匹配的患有 COVID-19 且无任何基础疾病的患者作为对照。
研究期间，共有 37968 名患者因 COVID-19 住院。其中有 18 名患者患有 DS。与无 DS 的患者相比，DS 患者更有可能被插管[7 名（39%）]；p = 0.002。与对照组相比，DS 患者因 COVID-19 死亡的比例显著更高[8 名（44.4%）比 1 名（1.9%）]；比值比：24.37；95%置信区间 2.39-247.94；p = 0.007。
DS 患者属于 COVID-19 高危人群，应尽快接种疫苗。此外，如果他们因 COVID-19 住院，应给予更强化的治疗。
