Cahill Thomas J, Kharbanda Rajesh K
Oxford Heart Centre, Oxford University Hospitals NHS Foundation Trust, Headley Way, Oxford, OX3 9DU UK.
Indian J Thorac Cardiovasc Surg. 2018 Dec;34(Suppl 3):206-212. doi: 10.1007/s12055-017-0637-4. Epub 2018 Feb 17.
Myocardial revascularisation has the potential to restore ventricular function and improve survival in patients with heart failure due to underlying coronary artery disease. Viability testing is routinely used to identify which patients are likely to benefit, given that revascularisation may entail substantial procedural risk. However, while the concept of viability testing and revascularisation of patients with 'hibernating myocardium' is strongly supported by observational series, randomised studies have failed to demonstrate clear benefit. This divergence in the evidence base is reflected in current European and US guidelines, in which viability testing has a class II recommendation. In this article, we review the current evidence for routine viability testing prior to revascularisation of patients with heart failure, outline its use in clinical practice and discuss ongoing trials in the field.
对于因潜在冠状动脉疾病导致心力衰竭的患者,心肌血运重建有可能恢复心室功能并提高生存率。鉴于血运重建可能带来重大的手术风险,目前常规使用存活心肌检测来确定哪些患者可能受益。然而,尽管“冬眠心肌”患者的存活心肌检测和血运重建概念得到了观察性系列研究的有力支持,但随机研究未能证明其有明显益处。这种证据基础的差异反映在当前欧洲和美国的指南中,其中存活心肌检测为II类推荐。在本文中,我们回顾了心力衰竭患者血运重建前常规进行存活心肌检测的现有证据,概述其在临床实践中的应用,并讨论该领域正在进行的试验。