Srivastava Swarnika, Bhan Anil
Department of cardiothoracic surgery, Medanta The Medicity hospital, Gurugram, India.
Noida, India.
Indian J Thorac Cardiovasc Surg. 2019 Jun;35(Suppl 2):136-155. doi: 10.1007/s12055-019-00819-w. Epub 2019 May 22.
The aortic arch repair is one of the most complex surgeries and carries a high risk of complications as well as mortality. Since 1975, when the arch repair was first done by Randall B. Griepp using hypothermic circulatory arrest, many new technologies were introduced. But even with the use of antegrade and retrograde perfusion techniques and improvement of surgical techniques and grafts, the rate of mortality, cerebral, spinal, and visceral damage was much higher as compared to any other cardiac surgeries. With further developments aimed at less invasive approaches, thoracic endovascular aortic repair (TEVAR) along with de-branching of supra-aortic vessels or the frozen elephant trunk was introduced. Here, in this article, we review the myriad of approaches to the aortic arch and have come to a conclusion that while traditional open surgery is considered as the gold standard for treatment of extensive aortic arch pathologies, one school of thought suggests hybrid techniques such as the frozen elephant trunk and aortic arch vessel de-branching as more appropriate procedures for high-risk patients, where co-morbidities may contraindicate cardiopulmonary bypass and longer operative times required for traditional repair. No randomized trials are present to compare between open and hybrid or endovascular procedure in normal or high-risk patients. The meta-analysis of most of the studies defines open surgery as the gold standard for arch pathology because the hybrid procedures did not provide any proven survival benefits or decrease in stroke rate and spinal ischemia when compared to open surgery in early, mid, or long-term results.
主动脉弓修复术是最复杂的手术之一,并发症风险和死亡率都很高。自1975年兰德尔·B·格里普首次使用低温循环停搏进行主动脉弓修复以来,引入了许多新技术。但即便采用了顺行和逆行灌注技术,以及手术技术和移植物的改进,与其他心脏手术相比,死亡率、脑、脊髓和内脏损伤的发生率仍要高得多。随着旨在采用微创方法的进一步发展,引入了胸主动脉腔内修复术(TEVAR)以及主动脉弓上血管去分支或“冰冻象鼻”技术。在本文中,我们回顾了主动脉弓的众多治疗方法,并得出结论:虽然传统开放手术被认为是治疗广泛性主动脉弓病变的金标准,但有一种观点认为,对于高风险患者,诸如“冰冻象鼻”和主动脉弓血管去分支等杂交技术是更合适的手术方式,这些患者的合并症可能会使体外循环成为禁忌,并且传统修复需要更长的手术时间。目前尚无随机试验来比较正常或高风险患者的开放手术与杂交手术或血管腔内手术。大多数研究的荟萃分析将开放手术定义为主动脉弓病变的金标准,因为与开放手术相比,杂交手术在早期、中期或长期结果中并未提供任何已证实的生存益处,也未降低卒中发生率和脊髓缺血发生率。