Yu Sanjiu, Lin Deqing, Yi Jianguang, Zhang Xianpu, Cheng Yongbo, Yan Chaojun, Zheng Huajie, Tang Lingfeng, Guo Mei, He Ping, Li Jun, Cheng Wei
Department of Cardiac Surgery, The First Hospital Affiliated to Army Medical University (Third Military Medical University), Chongqing, 400038, PR China.
Heliyon. 2024 Apr 3;10(7):e29106. doi: 10.1016/j.heliyon.2024.e29106. eCollection 2024 Apr 15.
Aortic surgery successfully improves the prognosis of patients with type A aortic dissection. However, total arch replacement and reconstruction remain challenging. This study presents a new surgical modality, the in-situ stent-graft fenestration (ISSF) technique, for simplifying aortic arch reconstruction and assesses its short-term efficacy and safety in patients with type A aortic dissection.
Data from 177 patients with type A aortic dissection who underwent aortic arch reconstruction were retrospectively analyzed. Sun's procedure was performed in 90 patients and ISSF was performed in the other 87.
The in-hospital mortality rate was 7.8% in the Sun's procedure group and 3.4% in the ISSF group ( = 0.357). Compared to the Sun's procedure group, the ISSF group had significantly shorter surgical duration, cardiopulmonary bypass time, circulatory arrest time, mechanical ventilation time, and aortic cross-clamp time ( < 0.05). Additionally, intraoperative blood loss was lower in the ISSF group than in the Sun's procedure group ( < 0.05). Patients who underwent ISSF also had a lower incidence of postoperative complications, including lung injury, renal failure, peripheral nerve injury, and chylothorax, than those who underwent Sun's procedure ( < 0.05). During the 6-month follow-up period after surgery, both groups showed significant improvements in the true lumen diameter of the descending thoracic aorta post-operation compared with the pre-operation measurements; meanwhile, the false lumen diameter decreased ( < 0.05).
The ISSF technique appears to be an effective and safe alternative to conventional surgical procedures for patients with type A aortic dissection, with the potential to simplify the procedure, shorten the operation time, and yield satisfactory operative results. However, further investigation is needed to determine its long-term benefits.
主动脉手术成功改善了A型主动脉夹层患者的预后。然而,全弓置换和重建仍然具有挑战性。本研究提出了一种新的手术方式,即原位支架移植物开窗术(ISSF)技术,用于简化主动脉弓重建,并评估其在A型主动脉夹层患者中的短期疗效和安全性。
回顾性分析177例行主动脉弓重建的A型主动脉夹层患者的数据。90例患者采用孙氏手术,另外87例采用ISSF手术。
孙氏手术组的院内死亡率为7.8%,ISSF组为3.4%(P = 0.357)。与孙氏手术组相比,ISSF组的手术时间、体外循环时间、循环阻断时间、机械通气时间和主动脉阻断时间均显著缩短(P < 0.05)。此外,ISSF组的术中出血量低于孙氏手术组(P < 0.05)。接受ISSF手术的患者术后并发症(包括肺损伤、肾衰竭、周围神经损伤和乳糜胸)的发生率也低于接受孙氏手术的患者(P < 0.05)。在术后6个月的随访期内,与术前测量值相比,两组患者术后降主动脉真腔直径均有显著改善;同时,假腔直径减小(P < 0.05)。
对于A型主动脉夹层患者,ISSF技术似乎是传统手术的一种有效且安全的替代方法,有可能简化手术过程、缩短手术时间并产生满意的手术效果。然而需要进一步研究以确定其长期益处。