Beeman Arun, Muthialu Nagarajan
Department of Cardiothoracic Surgery, Great Ormond Street Hospital for Children, WC1N 3JH, London, UK.
Indian J Thorac Cardiovasc Surg. 2020 Aug;36(Suppl 2):190-193. doi: 10.1007/s12055-020-00971-8. Epub 2020 Jun 22.
Pediatric heart transplantation has significantly improved in the survival of children with cardiomyopathy and/or complex congenital heart defects. With the increasing number of children needing transplantation, there is a growing demand for the organ, making it harder to cope with the increasing number of children on the waiting list. One of the advances that helped reduce the waiting list mortality significantly is the ability to transplant children from donors with ABO incompatibility. Modification of perfusion abilities and management of donor organ improves outcome in this select population, making ABO-incompatible transplantation an attractive option in the wider armamentarium available for pushing boundaries in these children without impacting on outcomes.
小儿心脏移植显著提高了患有心肌病和/或复杂先天性心脏缺陷儿童的生存率。随着需要移植的儿童数量不断增加，对器官的需求也日益增长，这使得应对等待名单上不断增加的儿童变得更加困难。有助于显著降低等待名单死亡率的一项进展是能够对ABO血型不相容的供体进行儿童心脏移植。灌注能力的改进和供体器官的管理改善了这一特定人群的治疗效果，使得ABO血型不相容移植成为在不影响治疗效果的前提下，拓展这些儿童治疗手段的更广泛方法中的一个有吸引力的选择。
