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在一群吸毒者中,更严重的疼痛与无法获得成瘾治疗有关。

Greater Pain Severity is Associated with Inability to Access Addiction Treatment Among a Cohort of People Who Use Drugs.

作者信息

Voon Pauline, Wang Linwei, Nosova Ekaterina, Hayashi Kanna, Milloy Michael John, Wood Evan, Kerr Thomas

机构信息

British Columbia Centre on Substance Use, Vancouver, BC V6Z 2A9, Canada.

School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

出版信息

J Pain Res. 2020 Oct 1;13:2443-2449. doi: 10.2147/JPR.S255438. eCollection 2020.

DOI:10.2147/JPR.S255438
PMID:33061559
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7534843/
Abstract

AIM

Given that co-occurring pain is prevalent among people who use drugs (PWUD), we sought to explore the effect of pain severity on accessing addiction treatment.

METHODS

Data were derived from two prospective cohort studies of PWUD in Vancouver, Canada from June 2014 to May 2016. Multivariable generalized linear mixed-effects multiple regression (GLMM) analyses were used to investigate the association between average pain severity and self-reported inability to access addiction treatment.

RESULTS

Among 1348 PWUD, 136 (10.1%) reported being unable to access addiction treatment at least once over the study period. Individuals who reported being unable to access addiction treatment had a significantly higher median average pain severity score (median=5, IQR=0-7) compared to individuals reporting no inability to access addiction treatment (median=3, IQR=0-6, =0.038). Greater pain severity was independently associated with higher odds of reporting inability to access addiction treatment (AOR: 1.75, 95%CI: 1.08-2.82 for mild-moderate vs no pain; AOR: 1.98, 95%CI: 1.27-3.09 for moderate-severe vs no pain).

CONCLUSION

PWUD with greater pain severity may be at higher risk of being unable to access addiction treatment, or vice versa. While further research is needed to confirm causal associations, these data suggest that there may be underlying pathways or mechanisms through which pain may be associated with access to addiction treatment for PWUD.

摘要

目的

鉴于并发疼痛在吸毒者中普遍存在,我们试图探讨疼痛严重程度对获得成瘾治疗的影响。

方法

数据来自2014年6月至2016年5月在加拿大温哥华进行的两项吸毒者前瞻性队列研究。采用多变量广义线性混合效应多元回归(GLMM)分析来研究平均疼痛严重程度与自我报告的无法获得成瘾治疗之间的关联。

结果

在1348名吸毒者中,136人(10.1%)报告在研究期间至少有一次无法获得成瘾治疗。报告无法获得成瘾治疗的个体的平均疼痛严重程度中位数得分(中位数=5,四分位间距=0-7)显著高于报告没有无法获得成瘾治疗的个体(中位数=3,四分位间距=0-6,P=0.038)。疼痛严重程度越高,报告无法获得成瘾治疗的几率越高(轻度至中度疼痛与无疼痛相比:调整后比值比[AOR]=1.75,95%置信区间[CI]:1.08-2.82;中度至重度疼痛与无疼痛相比:AOR=1.98,95%CI:1.27-3.09)。

结论

疼痛严重程度较高的吸毒者可能更难获得成瘾治疗,反之亦然。虽然需要进一步研究来证实因果关系,但这些数据表明,可能存在潜在的途径或机制,通过这些途径或机制,疼痛可能与吸毒者获得成瘾治疗有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49b0/7534843/8a2aa09682fe/JPR-13-2443-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49b0/7534843/8a2aa09682fe/JPR-13-2443-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49b0/7534843/8a2aa09682fe/JPR-13-2443-g0001.jpg

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