Gao Ya, Wu Xinyi, Li Yunhao, Li Yifei, Zhou Qingyu, Wang Qiongqiong, Wei Chaoyi, Shi Deli, Xie Congying, Pan Huanle
Department of Radiotherapy and Chemotherapy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
Cancer Manag Res. 2020 Sep 21;12:8695-8701. doi: 10.2147/CMAR.S268964. eCollection 2020.
To evaluate the predictive value of blood lymphocyte, monocyte to lymphocyte ratio (MLR), and neutrophil to lymphocyte ratio (NLR) for radiation pneumonia (RP) in patients with thoracic tumors receiving radiotherapy.
The clinical data of 65 patients with thoracic tumor (esophageal cancer, lung cancer) treated by radiotherapy in our hospital were retrospectively analyzed. Patients were divided into the RP group and the non-RP group according to the Common Terminology Criteria for Adverse Events (CTCAE 5.0). Data on blood cell counts, including lymphocytes, monocytes, and neutrophils, were collected before (0 weeks) and after 1, 2, and 4 weeks of radiotherapy.
Of the 65 patients enrolled, 27 developed radiation pneumonia and 38 did not. Patients' clinical factors, including age, TNM stage, tumor type, underlying lung disease, and history of smoking, had no correlation with RP. ANOVA of repeated measurement data showed that the changes of MLR in the group with RP during radiotherapy were significantly different from those in the non-RP group (<0.05). The RP prediction model based on the identified risk factors was established using receiver operator characteristic curves. The results showed that the area under the curve for the monocyte to lymphocyte ratio was 0.755 (95% CI, 0.63-0.87, =0.000), and the best cutoff point for MLR was 0.426.
MLR could predict radiation pneumonia in patients with thoracic tumor radiotherapy and achieve early monitoring, early prevention, and treatment.
评估血液淋巴细胞、单核细胞与淋巴细胞比值（MLR）以及中性粒细胞与淋巴细胞比值（NLR）对接受放疗的胸部肿瘤患者放射性肺炎（RP）的预测价值。
回顾性分析我院65例接受放疗的胸部肿瘤（食管癌、肺癌）患者的临床资料。根据不良事件通用术语标准（CTCAE 5.0）将患者分为RP组和非RP组。收集放疗前（0周）、放疗1周、2周和4周后的血细胞计数数据，包括淋巴细胞、单核细胞和中性粒细胞。
65例入选患者中，27例发生放射性肺炎，38例未发生。患者的临床因素，包括年龄、TNM分期、肿瘤类型、基础肺部疾病和吸烟史，与RP均无相关性。重复测量数据的方差分析显示，RP组放疗期间MLR的变化与非RP组相比有显著差异（<0.05）。利用受试者工作特征曲线建立基于识别出的危险因素的RP预测模型。结果显示，单核细胞与淋巴细胞比值的曲线下面积为0.755（95%CI，0.63 - 0.87，P = 0.000），MLR的最佳截断点为0.426。
MLR可预测胸部肿瘤放疗患者的放射性肺炎，并实现早期监测、早期预防和治疗。
