Zhang Yi, Chen Bo, Wang Lijuan, Wang Rong, Yang Xianjin
Department of General Surgery.
Department of Cardiology, the First People's Hospital of Neijiang, Neijiang, Sichuan Province.
Medicine (Baltimore). 2019 Jan;98(3):e13788. doi: 10.1097/MD.0000000000013788.
The prognostic value of pretreatment systemic immune-inflammation index (SII) in lung cancer has yet to be fully established.
Relevant articles were obtained by performing a systematic search. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were used to assess the relationship between SII index and overall survival (OS) in lung cancer; the OS was calculated from the time of cancer diagnosis to the date of death due to any cause or to the last date of follow-up.
In total, 2786 patients with lung cancer from 7 studies were included in this meta-analysis. The median thresholds to define high SII was 640 (range 395.4-1600) in the analyzed studies. The pooled HR for OS was 1.77 (95% CI: 1.54-2.00, P < .001), suggesting that the patients with a high SII score had a worse OS. In addition, results from subgroup meta-analysis showed the significant prognostic significance of SII in lung cancer. Especially, the predictive value of SII was significant in the multivariable model for NSCLC (HR: 1.97, 95% CI: 1.69-2.25, P < .001; 5 studies, 1746 patients), and SCLC (HR: 1.38, 95% CI: 1.02-1.85, P < .001; 1 study, 919 patients).
Our data suggest that high SII index indicates poor survival rate in lung cancer. Further researches are warranted to verify the significance of SII index in clinical practice.
肺癌患者治疗前的全身免疫炎症指数（SII）的预后价值尚未完全明确。
通过系统检索获取相关文章。采用风险比（HR）和95%置信区间（95%CI）评估SII指数与肺癌患者总生存期（OS）之间的关系；OS从癌症诊断时间计算至因任何原因死亡日期或最后随访日期。
本荟萃分析共纳入来自7项研究的2786例肺癌患者。分析的研究中定义高SII的中位数阈值为640（范围395.4 - 1600）。OS的合并HR为1.77（95%CI：1.54 - 2.00，P <.001），表明SII评分高的患者OS较差。此外，亚组荟萃分析结果显示SII在肺癌中具有显著的预后意义。特别是，SII在非小细胞肺癌（NSCLC）多变量模型中的预测价值显著（HR：1.97，95%CI：1.69 - 2.25，P <.001；5项研究，1746例患者），在小细胞肺癌（SCLC）中也显著（HR：1.38，95%CI：1.02 - 1.85，P <.001；1项研究，919例患者）。
我们的数据表明，高SII指数表明肺癌患者生存率低。有必要进一步研究以验证SII指数在临床实践中的意义。
