Mo Shao-Jian, Zhao Hai-Chao, Tian Yan-Zhang, Zhao Hao-Liang
Department of General Surgery, The Affiliated Bethune Hospital of Shanxi Medical University, Taiyuan 030032, People's Republic of China.
Department of General Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan 030032, People's Republic of China.
Cancer Manag Res. 2020 Sep 23;12:8847-8856. doi: 10.2147/CMAR.S270237. eCollection 2020.
Prefoldin (PFDN) is a hexameric chaperone complex that is widely found in eukaryotes and archaea and consists of six different subunits (PFDN1-6). Its main function is to transfer actin and tubulin monomers to the eukaryotic cell cytoplasmic chaperone protein (c-CPN) specific binding during the assembly of the cytoskeleton, to stabilize the newly synthesized peptides so that they can be folded correctly. The current study found that each subunit of PFDN has different functions, which are closely related to the occurrence, development and prognosis of tumors. However, the best characteristics of each subunit have not been fully affirmed. The connection between research and tumors can change the understanding of PFDN and further extend its potential prognostic role and structural function to cancer research and clinical practice. This article mainly reviews the role of canonical PFDN and its subunits in tumors and other diseases, and discusses the potential prospects of the unique structure and function of PFDN in nanomedicine.
预折叠蛋白（PFDN）是一种六聚体伴侣蛋白复合物，广泛存在于真核生物和古细菌中，由六个不同的亚基（PFDN1 - 6）组成。其主要功能是在细胞骨架组装过程中，将肌动蛋白和微管蛋白单体转移至真核细胞胞质伴侣蛋白（c - CPN）特异性结合，以稳定新合成的肽段，使其能够正确折叠。当前研究发现，PFDN的每个亚基都具有不同功能，这些功能与肿瘤的发生、发展及预后密切相关。然而，每个亚基的最佳特性尚未得到充分肯定。该研究与肿瘤之间的联系能够改变对PFDN的认识，并进一步将其潜在的预后作用和结构功能扩展至癌症研究及临床实践中。本文主要综述了典型PFDN及其亚基在肿瘤和其他疾病中的作用，并探讨了PFDN独特结构和功能在纳米医学中的潜在前景。
