Beauchamp Gillian A, Carey Jennifer L, Hurwitz Mikayla B, Tully Briana N, Cook Matthew D, Cannon Robert D, Katz Kenneth D, Koons Andrew L, Kincaid Hope, Greenberg Marna Rayl
Department of Emergency and Hospital Medicine, Lehigh Valley Health Network/University of South Florida (USF) Morsani College of Medicine, Allentown, PA 18103, USA.
Section of Medical Toxicology, Department of Emergency and Hospital Medicine, Lehigh Valley Health Network/USF Morsani College of Medicine, Allentown, PA 18103, USA.
Subst Abuse Rehabil. 2020 Sep 29;11:23-31. doi: 10.2147/SAR.S263165. eCollection 2020.
Variations between male and female populations are previously reported in classes of harmfully used/misused drugs, severity of substance use disorder and risk of relapse. The aim of this study was to provide a review of bedside medical toxicologist managed, sex-specific poisonings in adults that present with harmful drug use/misuse.
ToxIC Registry cases ≥19 and ≤65 years old, with harmful drug use or misuse during the timeframe June 2010-December 2016, were studied. Demographics, primary agents of toxic exposure, administration route and complications were analyzed. Descriptive methods were used in the analysis.
The database included 51,440 cases. Of these, 3426 cases were analyzed in which the primary reason for the encounter was harmful substance use/misuse. Females were found to harmfully use/misuse pharmaceutical drugs (N=806, 65.6%) more than nonpharmaceutical drugs (N=423, 34.4%). Males more frequently used nonpharmaceutical drugs (N=1189, 54.1%) than pharmaceutical drugs (1008, 45.9%). Analgesics were used by females (N= 215, 18.2%) and males (N=137, 6.6%). Sedative hypnotics were used by females (N=165, 14%) and males (N=160, 7.8%). Psychoactive agents were used by males (N=325, 15.8%) and females (N=67, 5.7%). Sympathomimetics were used by males (N=381, 18.5%) and females (N=151, 12.8%). The majority of both male and female participants, 1712 (57.9%), utilized an oral route of administration. However, 312 (16.5%) of males utilized inhalation vs 73 (6.8%) of females inhaled their substance.
There were sex-specific differences among patients evaluated for harmful substance use/misuse by toxicologists. Considering these differences in regards to management and preventive approaches may be indicated.
先前有报道称，在有害使用/滥用药物的类别、物质使用障碍的严重程度以及复发风险方面，男性和女性人群存在差异。本研究的目的是综述床边医学毒理学家处理的、成年患者中出现有害药物使用/滥用的性别特异性中毒情况。
研究了2010年6月至2016年12月期间年龄在19岁至65岁之间、有有害药物使用或滥用情况的ToxIC登记病例。分析了人口统计学、毒物暴露的主要药物、给药途径和并发症。分析采用描述性方法。
数据库包含51440例病例。其中，对3426例病例进行了分析，这些病例就诊的主要原因是有害物质的使用/滥用。发现女性有害使用/滥用药品（N = 806，65.6%）的情况多于非药品（N = 423，34.4%）。男性使用非药品（N = 1189，54.1%）的频率高于药品（1008，45.9%）。女性（N = 215，18.2%）和男性（N = 137，6.6%）都使用了镇痛药。女性（N = 165，14%）和男性（N = 160，7.8%）都使用了镇静催眠药。男性（N = 325，15.8%）和女性（N = 67，5.7%）都使用了精神活性药物。男性（N = 381，18.5%）和女性（N = 151，12.8%）都使用了拟交感神经药。大多数男性和女性参与者（1712例，57.9%）采用口服给药途径。然而，312例（16.5%）男性采用吸入方式，而女性采用吸入方式的有73例（6.8%）。
在毒理学家评估的有害物质使用/滥用患者中存在性别特异性差异。在管理和预防方法方面考虑这些差异可能是有必要的。
