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一名青春期女孩的α-硫辛酸中毒:病例报告及文献复习

Alpha-lipoic acid intoxication in an adolescent girl: Case report and review of the literature.

作者信息

Polat Sinem, Kılıçaslan Önder, Sönmez Feruza Turan

机构信息

Department of Pediatrics, Pediatric Intensive Care Unit, Istinye University Liv Hospital, İstanbul, Turkey.

Department of Pediatrics, Düzce University Faculty of Medicine, Düzce, Turkey.

出版信息

Turk Pediatri Ars. 2020 Sep 23;55(3):328-330. doi: 10.14744/TurkPediatriArs.2019.66564. eCollection 2020.

Abstract

Alpha-lipoic acid is a widely used medication that does not need a prescription. Although it is safely used in adults, hitherto no safe dose for children has been reported, and there is no known antidote. The medical literature provides four reports of alpha-lipoic acid intoxication in the pediatric population to date. This case-report is the lowest known dose of alpha-lipoic acid intake leading to poisoning in a teenager.

摘要

硫辛酸是一种广泛使用的无需处方的药物。虽然它在成人中使用安全,但迄今为止尚无儿童安全剂量的报告,也没有已知的解毒剂。医学文献中迄今已有4例关于儿科人群硫辛酸中毒的报告。本病例报告是已知导致青少年中毒的最低硫辛酸摄入量。

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Re: Alpha-lipoic acid intoxication in an adolescent girl.回复:一名青春期女孩的α-硫辛酸中毒事件。
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Alpha-lipoic acid intoxication in an adolescent girl.一名青春期女孩的α-硫辛酸中毒
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本文引用的文献

1
Antileukemic effects of piperlongumine and alpha lipoic acid combination on Jurkat, MEC1 and NB4 cells in vitro.
J Cancer Res Ther. 2016 Apr-Jun;12(2):556-60. doi: 10.4103/0973-1482.151936.
2
A rare cause of status epilepticus; alpha lipoic acid intoxication, case report and review of the literature.
Eur J Paediatr Neurol. 2015 Nov;19(6):730-2. doi: 10.1016/j.ejpn.2015.07.002. Epub 2015 Jul 18.
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Alpha lipoic acid intoxication, treatment and outcome.
Clin Toxicol (Phila). 2013 Jul;51(6):522. doi: 10.3109/15563650.2013.801983. Epub 2013 May 28.
5
Safety evaluation of alpha-lipoic acid (ALA).α-硫辛酸(ALA)的安全性评估。
Regul Toxicol Pharmacol. 2006 Oct;46(1):29-41. doi: 10.1016/j.yrtph.2006.06.004. Epub 2006 Aug 14.

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