Tóth Zoltán, Szalay Balázs, Gyarmati Béla, Jalal Dlovan Ali, Vásárhelyi Barna, Szabó Tamás
Department of Urology, Uzsoki Hospital, Budapest, Hungary.
Department of Laboratory Medicine, Semmelweis University, Budapest, Hungary.
EJIFCC. 2020 Sep 29;31(3):225-230. eCollection 2020 Sep.
Vitamin D deficiency has been linked to a higher risk of prostate cancer. We tested the hypothesis that vitamin D levels would have an impact on prostate specific antigen (PSA) levels.
From our laboratory database we selected 5136 male patients with simultaneously determined vitamin D and PSA levels. Subgroups of several age cohorts with different vitamin D levels were created and PSA 95 percentile values were assessed. The independent effect of vitamin D levels and age on PSA levels was determined with logistic regression.
PSA levels increased with age, while no difference was identified in PSA levels in different vitamin D subgroups.
Vitamin D levels do not have an effect on PSA. Hence, there is no need to adjust PSA reference ranges and threshold values to vitamin D levels during the process of decision making.
维生素D缺乏与前列腺癌风险较高有关。我们检验了维生素D水平会对前列腺特异性抗原（PSA）水平产生影响这一假设。
从我们的实验室数据库中，我们选取了5136名同时测定了维生素D和PSA水平的男性患者。创建了几个具有不同维生素D水平的年龄队列亚组，并评估了PSA的第95百分位数。通过逻辑回归确定维生素D水平和年龄对PSA水平的独立影响。
PSA水平随年龄增长而升高，而不同维生素D亚组的PSA水平未发现差异。
维生素D水平对PSA没有影响。因此，在决策过程中无需根据维生素D水平调整PSA参考范围和阈值。
