Asmerom Demoze, Kalay Tesfay Haile, Tafere Gebrehiwot Gebremedhin
Department of Medicinal Chemistry, School of Pharmacy, College of Health Sciences, Mekelle University, P.O. Box 1871, Mekelle, Ethiopia.
Department of Pharmacognosy, School of Pharmacy, College of Health Sciences, Mekelle University, P.O. Box 1871, Mekelle, Ethiopia.
Int J Microbiol. 2020 Sep 30;2020:8840857. doi: 10.1155/2020/8840857. eCollection 2020.
Infectious diseases caused by fungi and bacteria are among the major causes of illness and death worldwide. This is mainly implicated by the antimicrobial resistance of the current treatment regimens. Since plant products are house stores of bioactive compounds, it is essential to screen plant-based antimicrobials to come up with novel medicines that counter the grave consequences of antimicrobial resistance. In the folk medicine of Ethiopia, is used for the treatment of wound, dandruff, malaria, diabetes, impotence, colon cleansing, amoeba, ascariasis, abdominal pain, urine retention, snake bite, and evil eye. Hence, the present study was aimed to evaluate the antibacterial and antifungal effects of the leaf exudate of . Agar well diffusion was employed to determine the antibacterial and antifungal effects. Six bacterial strains, namely, (standard), (clinical isolate), ATCC 25922 (standard), (clinical isolate), (standard), and ATCC 27853 (standard), and four fungal strains such as , , , and were studied. The leaf exudate showed the highest activity against with an average zone diameter of 22.49 ± 0.47 mm at 400 mg/mL. Among the bacterial species, ATCC 29213 (standard) was the most sensitive with an average zone of diameter of 16.63 ± 0.12 mm at 200 mg/mL. Thus, the present findings support the folklore use of for the treatment of different microbial infections.
由真菌和细菌引起的传染病是全球疾病和死亡的主要原因之一。这主要与当前治疗方案的抗菌耐药性有关。由于植物产品是生物活性化合物的储存库，因此筛选基于植物的抗菌剂以开发出对抗抗菌耐药性严重后果的新型药物至关重要。在埃塞俄比亚的民间医学中，[植物名称]被用于治疗伤口、头皮屑、疟疾、糖尿病、阳痿、结肠清洁、阿米巴病、蛔虫病、腹痛、尿潴留、蛇咬伤和邪眼。因此，本研究旨在评估[植物名称]叶渗出物的抗菌和抗真菌作用。采用琼脂扩散法测定抗菌和抗真菌作用。研究了六种细菌菌株，即[细菌名称1]（标准菌株）、[细菌名称2]（临床分离株）、大肠杆菌ATCC 25922（标准菌株）、[细菌名称3]（临床分离株）、[细菌名称4]（标准菌株）和金黄色葡萄球菌ATCC 27853（标准菌株），以及四种真菌菌株，如[真菌名称1]、[真菌名称2]、[真菌名称3]和[真菌名称4]。叶渗出物对[细菌名称]表现出最高活性，在400mg/mL时平均抑菌圈直径为22.49±0.47mm。在细菌物种中，粪肠球菌ATCC 29213（标准菌株）最敏感，在200mg/mL时平均抑菌圈直径为16.63±0.12mm。因此，本研究结果支持了[植物名称]在民间医学中用于治疗不同微生物感染的用途。
