Hinther Kelsey, Henni Jihane, Asiniwasis Rachel N
Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
Department of Psychiatry, University of Calgary, Calgary, AB, Canada.
SAGE Open Med Case Rep. 2020 Sep 26;8:2050313X20953114. doi: 10.1177/2050313X20953114. eCollection 2020.
Microcystic adnexal carcinoma is a rare cutaneous neoplasm believed to arise from pluripotent keratinocytes capable of adnexal differentiation. Due to its insidious growth and appearance, diagnosis is often delayed. A deep incisional or excisional biopsy for histopathology is the gold standard for diagnosis. Different treatment modalities have been described in the literature, including the Mohs micrographic surgery, standard excision, radiation, chemotherapy, and observation. Currently, Mohs remains the treatment of choice. We present a unique case of a 12-month history of an extensive progressive centrofacial cutaneous induration diagnosed as microcystic adnexal carcinoma in an 83-year-old female. Due to the extensive nature of the tumor, she received radiation therapy and continues to receive ongoing assessment with no evidence of clinical recurrence at 2-year post-treatment including negative scouting biopsies. To date, there is no consensus on the optimal treatment for microcystic adnexal carcinoma.
微囊性附属器癌是一种罕见的皮肤肿瘤，被认为起源于能够进行附属器分化的多能角质形成细胞。由于其隐匿性生长和外观表现，诊断往往会延迟。进行深部切口活检或切除活检以获取组织病理学结果是诊断的金标准。文献中描述了不同的治疗方式，包括莫氏显微外科手术、标准切除术、放疗、化疗以及观察等待。目前，莫氏手术仍是首选的治疗方法。我们报告了一例独特的病例，一名83岁女性，面部中央皮肤出现广泛进行性硬结，病史长达12个月，诊断为微囊性附属器癌。由于肿瘤范围广泛，她接受了放射治疗，并且在治疗后2年持续接受评估，包括阴性探查活检，均未发现临床复发迹象。迄今为止，对于微囊性附属器癌的最佳治疗方法尚无共识。
