Billingsley E M, Fedok F, Maloney M E
Department of Medicine, Pennsylvania State University College of Medicine, Hershey, USA.
Arch Otolaryngol Head Neck Surg. 1996 Feb;122(2):179-82. doi: 10.1001/archotol.1996.01890140065012.
Microcystic adnexal carcinoma is an aggressive, locally destructive cutaneous neoplasm with a high rate of recurrence. This tumor is often misdiagnosed clinically and histologically. It usually occurs in middle-aged to older adults. We describe a 44-year-old man with a large microcystic adnexal carcinoma that was present for more than 20 years. The tumor invaded the perichondrium, muscle, nerve, and blood vessel adventitia. A review of the literature suggests that these tumors are often histologically misdiagnosed because the biopsy specimens may be too small to reveal all the characteristic histologic features. The clinical presence of marked induration, a smooth surface, and, possibly, sensory changes should alert the clinician to the possibility of this neoplasm. The initial biopsy specimen must be large enough to demonstrate the identifying histologic features. Mohs surgery is currently the treatment of choice for microcystic adnexal carcinoma, as it often spreads far beyond clinically evident tumor.
微囊性附属器癌是一种侵袭性、具有局部破坏性的皮肤肿瘤，复发率高。该肿瘤在临床和组织学上常被误诊。它通常发生于中老年人。我们描述了一名44岁男性，患有一个存在超过20年的巨大微囊性附属器癌。肿瘤侵犯了软骨膜、肌肉、神经和血管外膜。文献回顾表明，这些肿瘤在组织学上常被误诊，因为活检标本可能太小而无法显示所有特征性组织学特征。明显硬结、表面光滑以及可能存在感觉改变的临床表现应提醒临床医生注意这种肿瘤的可能性。初始活检标本必须足够大以显示特征性组织学特征。莫氏手术目前是微囊性附属器癌的首选治疗方法，因为它常常扩散到临床可见肿瘤范围之外。
