Al Khodari Khaled, Baig Tehniyat, Alkhateeb Mohammad Husni, Naeem Muhammad
Department of Internal Medicine, Hamad Medical Corporation (HMC), Doha, Qatar.
Weill Cornell Medicine-Qatar, Doha, Qatar.
SAGE Open Med Case Rep. 2020 Sep 30;8:2050313X20958548. doi: 10.1177/2050313X20958548. eCollection 2020.
Typhi is the main cause of an acute febrile, sometimes fatal, multisystemic illness called typhoid fever. The diverse presentations of this disease make it a diagnostic challenge in some patients. Involvement of the neurological system, including cochleovestibular system, is very rare with less than a handful of reported cases. This case report describes the condition of a previously healthy 23-year-old Pakistani man with acute onset of hearing loss associated with fever, headache, and disorientation. The most likely differential diagnoses were bacterial or viral meningoencephalitis, and other bacterial infections, such as Rickettsial and spirochetal diseases. Typhi grew on blood culture; thus, treatment with intravenous antibiotics and systemic steroids was provided with excellent response. Hearing loss gradually improved and almost completely resolved within 3 to 4 weeks.
伤寒杆菌是一种急性发热性、有时致命的多系统疾病——伤寒热的主要病因。这种疾病的多种表现使其在一些患者中成为诊断难题。神经系统受累，包括耳蜗前庭系统，非常罕见，报告病例不足少数几例。本病例报告描述了一名此前健康的23岁巴基斯坦男子的病情，他急性起病，伴有发热、头痛和定向障碍，并出现听力丧失。最可能的鉴别诊断是细菌性或病毒性脑膜脑炎，以及其他细菌感染，如立克次体病和螺旋体病。血培养发现伤寒杆菌；因此，给予静脉抗生素和全身类固醇治疗，反应良好。听力损失逐渐改善，在3至4周内几乎完全恢复。
