发现关联:川崎病与新型冠状病毒肺炎
Discovering Associations: Kawasaki Disease and COVID-19.
作者信息
Peterson Nicholas, Sagdeo Kaustubh, Tyungu Donna, Harper Cristin, Mihaylo Kyle, Pollak-Christian Elza
机构信息
The University of Oklahoma Health Sciences Center, Department of Pediatrics, Section of Pediatric Hospital Medicine, Oklahoma City, OK 73104, USA.
The University of Oklahoma Health Sciences Center, Department of Pediatrics, Pediatric Resident, Oklahoma City, OK 73104, USA.
出版信息
Case Rep Pediatr. 2020 Sep 28;2020:8880242. doi: 10.1155/2020/8880242. eCollection 2020.
The COVID-19 pandemic has resulted in over 3.6 million confirmed cases and over 254,000 deaths worldwide. It has been theorized that children who are asymptomatic or who do not display significant respiratory symptoms are potential vectors for community transmission of the SARS-CoV-2 virus. This is incompletely understood due to the current lack of widespread testing in the pediatric population. We describe a case of a 2-year-old female who presented with symptoms of prolonged fever, conjunctivitis, extremity edema, rash, dry/cracked lips, fussiness and fatigue, and a notable absence of respiratory symptoms. She was diagnosed with and treated for Kawasaki disease. Due to her prolonged fever, she was tested for COVID-19 which was positive; however, she did not develop respiratory symptoms during her illness. At the time of manuscript submission, this is the second case report to our knowledge showing an association between Kawasaki Disease and SARS-CoV-2 virus, both of which are poorly understood diseases in the pediatric population. This case highlights the value of testing pediatric patients for COVID-19 who present with fever in the absence of other symptoms to improve epidemiologic measures during the ongoing pandemic, and it also adds to a foundation of cases for future research on the presence of a link between Kawasaki Disease and COVID-19.
新冠疫情已在全球导致超过360万确诊病例和超过25.4万例死亡。据推测,无症状或未表现出明显呼吸道症状的儿童可能是新冠病毒社区传播的潜在载体。由于目前儿科人群中缺乏广泛检测,对此尚不完全清楚。我们描述了一名2岁女性病例,她出现持续发热、结膜炎、肢体水肿、皮疹、嘴唇干裂、烦躁和疲劳等症状,且明显没有呼吸道症状。她被诊断为川崎病并接受了治疗。由于她持续发热,接受了新冠病毒检测,结果呈阳性;然而,她在患病期间并未出现呼吸道症状。在提交本稿件时,据我们所知,这是第二例显示川崎病与新冠病毒之间存在关联的病例报告,这两种疾病在儿科人群中都了解甚少。该病例凸显了对无其他症状仅发热的儿科患者进行新冠病毒检测的价值,以在当前疫情期间改进流行病学措施,同时也为未来关于川崎病与新冠病毒之间联系的研究增添了病例基础。