Terao Etsuko, Nakakura Shunsuke, Nagata Yuki, Dote Saki, Tabuchi Hitoshi, Kiuchi Yoshiaki
Ophthalmology, Saneikai Tsukazaki Hospital, Himeji, JPN.
Ophthalmology, Hiroshima University, Hiroshima, JPN.
Cureus. 2020 Sep 10;12(9):e10368. doi: 10.7759/cureus.10368.
To evaluate the pattern of conjunctival hyperemia induced by omidenepag isopropyl 0.002% and ripasudil 0.4%, and its correlation with the degree of hyperemia.
We previously reported the time course of conjunctival hyperemia induced by administering one drop of omidenepag isopropyl to one eye and one drop of ripasudil to the other eye in 34 healthy subjects (mean age: 29.7 years; 22 females, 12 males). We assessed the degree of hyperemia by slit-lamp photography of the frontal and temporal conjunctiva 0, 15, 30, 60, 120, 180, and 360 min after the administration of one drop of omidenepag isopropyl and ripasudil. The data were used to compare the frontal photographs before and at the peak of hyperemia according to the clinical hyperemia score (0-3) and classify the pattern of developing hyperemia due to both drugs. We also examined the correlation between the degree of hyperemia by comparing the images captured at the peak of hyperemia in both groups, using clinical hyperemia score and "percent coverage" of conjunctival hyperemia by using an automated hyperemia analysis software program; this program provides the pixel coverage of the conjunctival vessels in the region of interest. Results: There were significant differences in the developmental pattern of hyperemia between omidenepag isopropyl-administered and ripasudil-administered eyes (P<0.001, χ test), with dilation of large blood vessels only (N=2 vs. 1, respectively), small blood vessels only (N=17 vs. 5), both large and small blood vessels (N=8 vs. 27), and no change (N=6 vs. 0). The degree of hyperemia between the two groups was positively correlated with the hyperemia score (rs=0.344, P=0.055) in the frontal conjunctival photographs and the percent coverage of conjunctival blood vessels (r=0.510, P=0.003) in the temporal conjunctival photographs.
The pattern of conjunctival hyperemia induced by omidenepag isopropyl predominantly involved small blood vessels, whereas that of ripasudil involved both large and small blood vessels. The eyes that were hyperemic with omidenepag isopropyl also tended to be hyperemic with ripasudil.
评估0.002%异丙基奥米地帕格和0.4%瑞巴派特诱导的结膜充血模式及其与充血程度的相关性。
我们之前报道了34名健康受试者（平均年龄：29.7岁；女性22名，男性12名）单眼滴入一滴异丙基奥米地帕格，另一只眼滴入一滴瑞巴派特后结膜充血的时间进程。我们在滴入一滴异丙基奥米地帕格和瑞巴派特后的0、15、30、60、120、180和360分钟，通过裂隙灯拍摄额侧和颞侧结膜来评估充血程度。根据临床充血评分（0 - 3分），比较充血高峰时与充血前的额侧照片数据，并对两种药物引起的充血发展模式进行分类。我们还通过比较两组充血高峰时拍摄的图像，使用临床充血评分和自动充血分析软件程序计算结膜充血的“覆盖百分比”来检查充血程度之间的相关性；该程序提供感兴趣区域内结膜血管的像素覆盖情况。结果：异丙基奥米地帕格组和瑞巴派特组的充血发展模式存在显著差异（P<0.001，χ检验），仅大血管扩张（分别为N = 2对1）、仅小血管扩张（N = 17对5）、大小血管均扩张（N = 8对27）以及无变化（N = 6对0）。两组之间的充血程度与额侧结膜照片中的充血评分（rs = 0.344，P = 0.055）以及颞侧结膜照片中结膜血管的覆盖百分比（r = 0.510，P = 0.003）呈正相关。
异丙基奥米地帕格诱导的结膜充血模式主要累及小血管，而瑞巴派特诱导的结膜充血模式则累及大小血管。滴入异丙基奥米地帕格后出现充血的眼睛，滴入瑞巴派特后也往往会出现充血。
