与阿法雄酮（RAD-140）和阿法精英（RAD-140和LGD-4033）相关的药物性肝损伤。
Drug-Induced Liver Injury Associated With Alpha Bolic (RAD-140) and Alpha Elite (RAD-140 and LGD-4033).
作者信息
Barbara Mary, Dhingra Sadhna, Mindikoglu Ayse L
机构信息
Margaret M. and Albert B. Alkek Department of Medicine, Section of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, TX.
Michael E. DeBakey Department of Surgery, Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX.
出版信息
ACG Case Rep J. 2020 Jun 18;7(6):e00409. doi: 10.14309/crj.0000000000000409. eCollection 2020 Jun.
We report a 52-year-old man who developed drug-induced liver injury after taking Alpha Bolic (contains RAD-140) and Alpha Elite (contains both RAD-140 and LGD-4033) supplements. Liver biopsy demonstrated diffuse centrilobular canalicular cholestasis, prominent ductular reaction, and mild lobular inflammation with rare non-necrotizing epithelioid granuloma suggestive of drug-induced liver injury. Liver enzymes returned to normal levels approximately 3 months after the patient stopped both supplements. We present the mechanism of drug-induced liver injury associated with 2 selective androgen receptor modulators, including RAD-140 and LGD 4033.
我们报告了一名52岁男性，他在服用Alpha Bolic（含RAD-140）和Alpha Elite（含RAD-140和LGD-4033）补充剂后发生药物性肝损伤。肝活检显示弥漫性小叶中央胆管胆汁淤积、显著的小胆管反应以及轻度小叶炎症，伴有罕见的非坏死性上皮样肉芽肿，提示药物性肝损伤。在患者停用这两种补充剂后约3个月，肝酶恢复至正常水平。我们阐述了与两种选择性雄激素受体调节剂（包括RAD-140和LGD 4033）相关的药物性肝损伤机制。
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