收容所内伴侣动物中氟喹诺酮耐药性的流行情况及机制
Prevalence and mechanisms of fluoroquinolone-resistant among sheltered companion animals.
作者信息
Umeda Kaoru, Hase Atsushi, Fukuda Akira, Matsuo Masashi, Horimoto Tomoaki, Ogasawara Jun
机构信息
Division of Microbiology, Osaka Institute of Public Health, 8-34, Tojo-cho, Tennoji-ku, Osaka 543-0026, Japan.
Osaka Municipal Animal Care and Control Center, 2-5-74, Shibatani, Suminoe-ku, Osaka 559-0021, Japan.
出版信息
Access Microbiol. 2019 Nov 5;2(1):acmi000077. doi: 10.1099/acmi.0.000077. eCollection 2020.
To better understand the prevalence of fluoroquinolone-resistant among sheltered companion animals, we conducted a screening study of 38 dogs and 78 cats and investigated the resistance mechanisms and characteristics of the isolates. Fluoroquinolone-resistant was detected in 18 dogs (47.4 %) and 14 cats (17.9 %). The isolates carried one to four mutations in the A, C and E genes of the quinolone resistance-determining region, and the number of mutations was proportional to the MIC for ciprofloxacin. For plasmid-mediated quinolone resistance, was detected in nine isolates, S in five isolates and B in one isolate. A relationship between the presence of these genes and MIC for ciprofloxacin was not apparent. Statistical analysis indicated that fluoroquinolone-resistant was widely distributed among sheltered companion animals with various attributes. This may relate to the wide dissemination of fluoroquinolone resistance among humans and other animals in Japan.
为了更好地了解庇护所内伴侣动物中氟喹诺酮耐药性的流行情况，我们对38只狗和78只猫进行了一项筛查研究，并调查了分离株的耐药机制和特征。在18只狗（47.4%）和14只猫（17.9%）中检测到氟喹诺酮耐药性。分离株在喹诺酮耐药决定区的A、C和E基因中携带1至4个突变，且突变数量与环丙沙星的最低抑菌浓度成正比。对于质粒介导的喹诺酮耐药性，在9个分离株中检测到，在5个分离株中检测到S，在1个分离株中检测到B。这些基因的存在与环丙沙星的最低抑菌浓度之间的关系并不明显。统计分析表明，氟喹诺酮耐药性在具有各种属性的庇护所内伴侣动物中广泛分布。这可能与氟喹诺酮耐药性在日本人类和其他动物中的广泛传播有关。
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