Department of Internal Medicine, Division Vascular Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Scand J Rheumatol. 2021 Mar;50(2):153-160. doi: 10.1080/03009742.2020.1780310. Epub 2020 Oct 16.
: Low body weight is an easily assessable cause of Raynaud's phenomenon (RP), and is frequently overlooked by clinicians. We aim to investigate the association of low body weight (body mass index < 18.5 kg/m), involuntary weight loss, and nutritional restrictions with the presence of RP.: Participants from the Lifelines Cohort completed a validated self-administered connective tissue disease questionnaire. Subjects who reported cold-sensitive fingers and biphasic or triphasic colour changes were considered to suffer from RP. Patient characteristics, anthropometric measurements, and nutritional habits were collected. Statistical analyses was stratified for gender.: Altogether, 93 935 participants completed the questionnaire. The prevalence of RP was 4.2% [95% confidence interval (CI) 4.1-4.4%], and was three-fold higher in women than in men (5.7% vs 2.1%, p < 0.001). Subjects with RP had a significantly lower daily caloric intake than those without RP. Multivariate analysis, correcting for creatinine level, daily caloric intake, and other known aetiological factors associated with RP, revealed that low body weight [men: odds ratio (OR) 5.55 (95% CI 2.82-10.93); women: 3.14 (2.40-4.10)] and involuntary weight loss [men: OR 1.32 (1.17-1.48); women: 1.31 (1.20-1.44)] were significantly associated with the presence of RP. Low-fat diet was also associated with RP in women [OR 1.27 (1.15-1.44)].: Low body weight and prior involuntary weight loss are associated with an increased risk of RP in both men and women. This study emphasizes that low body weight and weight loss are easily overlooked risk factors for RP, and should be assessed and monitored in subjects with RP.
体重过低是雷诺现象（RP）的一个易于评估的原因，经常被临床医生忽视。我们旨在研究低体重（体重指数 < 18.5 kg/m）、非自愿性体重减轻和营养限制与 RP 存在之间的关联。来自 Lifelines 队列的参与者完成了一份经过验证的自身免疫性结缔组织疾病问卷。报告手指对寒冷敏感且呈双相或三相颜色变化的患者被认为患有 RP。收集了患者特征、人体测量学测量值和营养习惯。统计分析按性别分层。
共有 93935 名参与者完成了问卷。RP 的患病率为 4.2%（95%置信区间[CI]为 4.1-4.4%），女性是男性的三倍（5.7%比 2.1%，p<0.001）。患有 RP 的患者的每日热量摄入明显低于没有 RP 的患者。多元分析，校正肌酐水平、每日热量摄入和其他与 RP 相关的已知病因因素，显示体重过低[男性：比值比（OR）5.55（95%CI 2.82-10.93）；女性：3.14（2.40-4.10）]和非自愿性体重减轻[男性：OR 1.32（1.17-1.48）；女性：1.31（1.20-1.44）]与 RP 的存在显著相关。低脂肪饮食也与女性的 RP 相关[OR 1.27（1.15-1.44）]。
体重过低和先前的非自愿性体重减轻与男性和女性的 RP 风险增加相关。本研究强调，体重过低和体重减轻是 RP 容易被忽视的危险因素，应在 RP 患者中进行评估和监测。
