Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Allergy and Clinical Immunology Unit, Center for the Diagnosis and Treatment of Osteoporosis, AUSL 04 Teramo, 64100 Teramo, Italy.
Int J Mol Sci. 2021 May 10;22(9):5043. doi: 10.3390/ijms22095043.
Immune, neuroendocrine, and autonomic nervous system dysregulation in anorexia nervosa lead to cardiovascular complications that can potentially result in increased morbidity and mortality. It is suggested that a complex non-invasive assessment of cardiovascular autonomic regulation-cardiac vagal control, sympathetic vascular activity, and cardiovascular reflex control-could represent a promising tool for early diagnosis, personalized therapy, and monitoring of therapeutic interventions in anorexia nervosa particularly at a vulnerable adolescent age. In this view, we recommend to consider in the diagnostic route, at least in the subset of patients with peripheral microvascular symptoms, a nailfold video-capillaroscopy as an easy not invasive tool for the early assessing of possible cardiovascular involvement.
厌食症患者的免疫系统、神经内分泌系统和自主神经系统失调会导致心血管并发症，从而增加发病率和死亡率。有人提出，对心血管自主调节（心脏迷走神经控制、交感血管活动和心血管反射控制）进行复杂的非侵入性评估，可能是厌食症早期诊断、个性化治疗和监测治疗干预的有前途的工具，特别是在易受伤害的青少年时期。有鉴于此，我们建议在诊断过程中，至少在有周围微血管症状的患者亚组中，考虑使用甲襞视频微血管检查作为一种简单的非侵入性工具，早期评估可能存在的心血管受累情况。
