van de Zande Saskia Corine, Eijkelenkamp Karin, Eman Abdulle Amaal, Smit Andries Jan, Zwerver Johannes, van den Akker-Scheek Inge, Mulder Douwe Johannes
Division of Vascular Medicine, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Department of Endocrinology and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Clin Rheumatol. 2025 Apr 17. doi: 10.1007/s10067-025-07416-w.
Women with primary Raynaud's phenomenon (RP) often experience a decreased health-related quality of life (HRQoL). A physically active lifestyle could improve vascular function and HRQoL.
This study aimed to quantify the amount and type of physical activity (PA) and sedentary behaviour, as well as HRQoL and stress, in women with primary RP from a large population-based cohort (Lifelines).
A total of 19,820 adult (≥ 18 years) women from the Lifelines cohort were included; 929 of these were classified as having RP based on the connective tissue disease (CTD) screening questionnaire. Participant characteristics, data on PA and sedentary behaviour, HRQoL and stress were retrieved from the database.
Women with RP reported 300 min/week minutes of moderate-to-vigorous physical activity (MVPA), which was more than women without RP (255 min/week, p ≤ .001). Women (74%) with RP complied to health enhancing PA guidelines (70% of women without RP, p = .003). Sedentary time was comparable. Women with RP had a low score on almost all eight domains of the HRQoL questionnaire. The Long-term Difficulties Inventory (LDI) showed a high stress level in the RP group (p < .001).
Most women with RP reported to spent a sufficient amount of time on MVPA and thus comply to health enhancing PA guidelines. The PA and sedentary behaviour of women with RP seems comparable to that of women without RP. However, HRQoL was lower and stress levels were higher in women with RP; more research is needed to elucidate the relation between PA and HRQoL in RP. Key Points • Experiencing symptoms of Raynaud's phenomenon seem no obstacle for being physically active. • Focus on women with symptoms of Raynaud's phenomenon in a large cohort. • Nearly 75% of the women with symptoms of Raynaud's phenomenon comply to the physical activity guidelines. • Women with symptoms of Raynaud's phenomenon have low levels of health-related quality of life and experience a high stress level.
原发性雷诺现象（RP）女性的健康相关生活质量（HRQoL）往往下降。积极的生活方式可改善血管功能和HRQoL。
本研究旨在量化来自大型人群队列（生命线研究）的原发性RP女性的身体活动（PA）量、类型、久坐行为、HRQoL及压力。
共纳入19820名来自生命线队列的成年（≥18岁）女性；其中929名根据结缔组织病（CTD）筛查问卷被归类为患有RP。从数据库中获取参与者特征、PA和久坐行为数据、HRQoL及压力数据。
患有RP的女性报告每周进行300分钟中等至剧烈身体活动（MVPA），多于无RP的女性（每周255分钟，p≤0.001）。患有RP的女性（74%）符合促进健康的PA指南（无RP女性为70%，p = 0.003）。久坐时间相当。患有RP的女性在HRQoL问卷的几乎所有八个领域得分都很低。长期困难量表（LDI）显示RP组压力水平较高（p < 0.001）。
大多数患有RP的女性报告在MVPA上花费了足够时间，因此符合促进健康的PA指南。患有RP的女性的PA和久坐行为似乎与无RP的女性相当。然而，患有RP的女性HRQoL较低且压力水平较高；需要更多研究来阐明PA与RP中HRQoL之间的关系。要点• 出现雷诺现象症状似乎不妨碍进行身体活动。• 在大型队列中关注有雷诺现象症状的女性。• 近75%有雷诺现象症状的女性符合身体活动指南。• 有雷诺现象症状的女性健康相关生活质量水平较低且压力水平较高。
