Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Immunology, Shahid Sadoughi University of Medical Sciences, International Campus, Yazd, Iran.
J Obstet Gynaecol. 2021 Jul;41(5):774-778. doi: 10.1080/01443615.2020.1798906. Epub 2020 Oct 16.
Natural killer group 2, member D () is one of the best known activating receptors of NK cells, which recognises its ligand on altered or stressed cells and activates NK cells to kill them. In this study, the single nucleotide polymorphism of the gene for rs1049174 mutation was compared in 140 women with recurrent spontaneous abortion (RSA) and 175 control women with at least one successful pregnancy and without any known pregnancy loss. The findings just revealed that GG genotype and G allele were significantly higher in the case group compared with the control group ( < .001). Our results regarding decreased risk of RSA in C allele (OR = 0.438; 95%CI = 0.310-0.619; < .001), and GC genotype (OR = 0.492; 95%CI = 0.214-0.574; < .001) compared with G allele and GG genotype respectively. This study demonstrated a significant association between gene polymorphism (rs1049174 G/C) and the risk of RSA in Iranian women.Impact statement According to previous investigations, maternal immune responses may affect the foetus, causing recurrent spontaneous abortion (RSA). The main cause of RSA has not yet been detected in nearly 50% of the cases. The results showed that the frequency of G allele and C allele were significantly different in the case group and control group. The results suggest a protective function of C allele because it significantly decreased the risk of RSA compared to G allele. It improves inhibition of NK cells and probably participates in maintaining pregnancy in fertile controls; whereas, G allele is related to a slight inhibition of NK cells, probably leading to increase effectiveness of NK activation and undesirable inflammation, which consequently causes foetal rejection.
自然杀伤细胞群 2 成员 D () 是 NK 细胞中最著名的激活受体之一，它识别其配体在改变或应激细胞上，并激活 NK 细胞杀死它们。在这项研究中，比较了 140 例复发性自然流产 (RSA) 妇女和 175 例至少有一次成功妊娠且无任何已知妊娠丢失的对照妇女的 基因 rs1049174 突变的单核苷酸多态性。结果表明，与对照组相比，病例组 GG 基因型和 G 等位基因显著升高（<0.001）。我们的结果表明，C 等位基因（OR=0.438；95%CI=0.310-0.619；<0.001）可降低 RSA 的风险，与 G 等位基因和 GG 基因型相比，GC 基因型（OR=0.492；95%CI=0.214-0.574；<0.001）可降低 RSA 的风险。这项研究表明，伊朗妇女 基因多态性（rs1049174 G/C）与 RSA 风险之间存在显著关联。
影响陈述
根据以前的研究，母体免疫反应可能会影响胎儿，导致复发性自然流产（RSA）。在近 50%的病例中，尚未发现 RSA 的主要原因。结果表明，病例组和对照组的 G 等位基因和 C 等位基因的频率有显著差异。结果表明，C 等位基因具有保护作用，因为与 G 等位基因相比，它显著降低了 RSA 的风险。它可以改善对 NK 细胞的抑制作用，可能参与维持肥沃对照组的妊娠；而 G 等位基因与 NK 细胞的轻微抑制有关，可能导致 NK 激活的有效性增加和不良炎症，从而导致胎儿排斥。
