Clark Jayden, Zhu Zhendan, Chuckowree Jyoti, Dickson Tracey, Blizzard Catherine
Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Neural Regen Res. 2021 Apr;16(4):618-620. doi: 10.4103/1673-5374.295312.
Central nervous system injury, specifically traumatic brain and spinal cord injury, can have significant long lasting effects. There are no comprehensive treatments to combat the injury and sequalae of events that occurring following a central nervous system trauma. Herein we discuss the potential for the epothilone family of microtubule stabilizing agents to improve outcomes following experimentally induced trauma. These drugs, which are able to cross the blood-brain barrier, may hold great promise for the treatment of central nervous system trauma and the current literature presents the extensive range of beneficial effects these drugs may have following trauma in animal models. Importantly, the effect of the epothilones can vary and our most recent contributions to this field indicate that the efficacy of epothilones following traumatic brain injury is dependent upon the age of the animals. Therefore, we present a case for a greater emphasis to be placed upon age when using an intervention aimed at neural regeneration and highlight the importance of tailoring the therapeutic regime in the clinic to the age of the patient to promote improved patient outcomes.
中枢神经系统损伤，特别是创伤性脑损伤和脊髓损伤，可产生重大的长期影响。目前尚无全面的治疗方法来对抗中枢神经系统创伤后发生的损伤和后遗症。在此，我们讨论埃坡霉素家族微管稳定剂在改善实验性诱导创伤后预后方面的潜力。这些能够穿过血脑屏障的药物，可能对治疗中枢神经系统创伤具有巨大潜力，并且当前文献展示了这些药物在动物模型创伤后可能具有的广泛有益作用。重要的是，埃坡霉素的效果可能有所不同，我们在该领域最近的研究表明，创伤性脑损伤后埃坡霉素的疗效取决于动物的年龄。因此，我们提出在使用旨在促进神经再生的干预措施时应更加重视年龄，并强调在临床中根据患者年龄调整治疗方案以促进改善患者预后的重要性。
