Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari.
Int J Dev Biol. 2020;64(7-8-9):397-407. doi: 10.1387/ijdb.200020dr.
Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. It requires the coordinated interplay of multiple types of epithelial cells with the surrounding extracellular matrix. Cell migration, proliferation, and extracellular matrix dynamics have different roles in driving budding in different organs. This historical review article summarizes the first founding literature data concerning branching morphogenesis occurring in kidney, lung, vascular system, mammary glands and neurons.
分支形态发生，即生物体中分支结构的形成，是动物和植物发育的关键特征。它需要多种类型的上皮细胞与周围细胞外基质的协调相互作用。细胞迁移、增殖和细胞外基质动力学在不同器官的芽生中发挥不同的作用。这篇历史综述文章总结了关于肾脏、肺、血管系统、乳腺和神经元中发生的分支形态发生的第一篇原始文献数据。
