Spurlin James W, Nelson Celeste M
Departments of Chemical and Biological Engineering, Princeton University, 303 Hoyt Laboratory, William Street, Princeton, NJ 08544, USA.
Departments of Chemical and Biological Engineering, Princeton University, 303 Hoyt Laboratory, William Street, Princeton, NJ 08544, USA
Philos Trans R Soc Lond B Biol Sci. 2017 May 19;372(1720). doi: 10.1098/rstb.2015.0527.
Branched networks are ubiquitous throughout nature, particularly found in tissues that require large surface area within a restricted volume. Many tissues with a branched architecture, such as the vasculature, kidney, mammary gland, lung and nervous system, function to exchange fluids, gases and information throughout the body of an organism. The generation of branched tissues requires regulation of branch site specification, initiation and elongation. Branching events often require the coordination of many cells to build a tissue network for material exchange. Recent evidence has emerged suggesting that cell cooperativity scales with the number of cells actively contributing to branching events. Here, we compare mechanisms that regulate branching, focusing on how cell cohorts behave in a coordinated manner to build branched tissues.This article is part of the themed issue 'Systems morphodynamics: understanding the development of tissue hardware'.
分支网络在自然界中无处不在，尤其存在于在有限体积内需要大表面积的组织中。许多具有分支结构的组织，如脉管系统、肾脏、乳腺、肺和神经系统，其功能是在生物体全身交换液体、气体和信息。分支组织的生成需要对分支位点的指定、起始和延伸进行调控。分支事件通常需要许多细胞协同作用来构建用于物质交换的组织网络。最近有证据表明，细胞协同性与积极参与分支事件的细胞数量成比例。在这里，我们比较调控分支的机制，重点关注细胞群体如何以协调的方式构建分支组织。本文是主题为“系统形态动力学：理解组织硬件的发育”这一特刊的一部分。
