Han Seung Cheol, Park Jeong Hwan, Hong Seung No
Department of Otorhinolaryngology, 65633Seoul National University College of Medicine, SMG-SNU Boramae Medical Center, Seoul, South Korea.
Department of Pathology, 58927Seoul National University College of Medicine, SMG-SNU Boramae Medical Center, Seoul, South Korea.
Ear Nose Throat J. 2021 Sep;100(8):557-561. doi: 10.1177/0145561320964266. Epub 2020 Oct 16.
Eosinophilic angiocentric fibrosis (EAF) is a rare and slowly progressive disease, which usually involves the sino-nasal structures and upper respiratory tract. It is a fibroinflammatory lesion with an unclear etiology. Recent literature suggests a relation to rheumatic or immunological disorders. Therefore, immunophenotypic workup is critical when suspected. We report a case of a 32-year-old man complaining of nasal obstruction lasting more than 2 years. Nasal endoscopy and computed tomography showed a deviated septum with bilateral soft tissue swelling. During the septoturbinoplasty, a submucosal mass with severe adhesion was observed beneath the septal flap. The mass was completely removed. Dense stromal fibrosis with eosinophil-rich inflammatory cell infiltration was found on histologic examination and the patient was diagnosed with EAF. In addition, we reviewed the pathologic diagnostic criteria, differential diagnosis, and management of EAF.
嗜酸性粒细胞性血管中心性纤维化（EAF）是一种罕见的、进展缓慢的疾病，通常累及鼻窦结构和上呼吸道。它是一种病因不明的纤维炎性病变。近期文献表明其与风湿性或免疫性疾病有关。因此，疑似病例进行免疫表型检查至关重要。我们报告一例32岁男性，主诉鼻塞持续超过2年。鼻内镜检查和计算机断层扫描显示鼻中隔偏曲伴双侧软组织肿胀。在鼻中隔鼻甲成形术中，在鼻中隔瓣下方观察到一个有严重粘连的黏膜下肿块。该肿块被完全切除。组织学检查发现致密的间质纤维化伴富含嗜酸性粒细胞的炎性细胞浸润，患者被诊断为EAF。此外，我们还回顾了EAF的病理诊断标准、鉴别诊断和治疗方法。
