Mizoram University, Biotechnology, Aizawl, Mizoram 796004, India.
Cachar Cancer Hospital & Research Centre, Research Silchar, 788015, India.
Biomark Med. 2020 Oct;14(14):1371-1382. doi: 10.2217/bmm-2020-0206. Epub 2020 Oct 16.
To evaluate the expression pattern of ALDH1 (aldehyde dehydrogenase 1), E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer (CRC) and to study association of their expression with the occurrence of CRC at a young age. Immunohistochemistry of ALDH1, E-cadherin, Vimentin and Twist was performed on 103 pretreated CRC biopsy samples. ALDH1 expression was found to have strong correlation with early onset CRC (p < 0.0001). High ALDH1 expression correlates with the early onset of CRC. ALDH1 over-expression correlates with poor overall survival in colon cancer.
评估醛脱氢酶 1（aldehyde dehydrogenase 1，ALDH1）、E-钙黏蛋白、波形蛋白和 Twist 在早发性和晚发性散发性结直肠癌（CRC）中的表达模式，并研究其表达与年轻CRC 发生的相关性。对 103 例预处理的 CRC 活检样本进行 ALDH1、E-钙黏蛋白、波形蛋白和 Twist 的免疫组织化学检测。结果发现，ALDH1 的表达与早发性 CRC 有很强的相关性（p<0.0001）。ALDH1 的高表达与 CRC 的早发相关。ALDH1 的过表达与结肠癌患者的总生存率降低相关。
