Katz Sophie E, Crook Jennifer, McHenry Rendie, Szeles Andras, Halasa Natasha, Banerjee Ritu
Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, USA.
College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA.
Infect Dis Ther. 2021 Mar;10(1):595-603. doi: 10.1007/s40121-020-00358-7. Epub 2020 Oct 16.
The kinetics of procalcitonin in pediatric patients with non-critical acute bacterial infections receiving appropriate antibiotic therapy are not well described.
We performed a single-center, prospective observational pilot study of children admitted to a tertiary care children's hospital who were receiving antibiotics for treatment of a non-critical acute bacterial infection, and we prospectively measured serial procalcitonin levels daily for 4 days during hospitalization.
Among the 46 children with baseline procalcitonin levels enrolled in the study, procalcitonin kinetics followed a half-life of approximately 24 h in most patients. Procalcitonin declined faster than C-reactive protein over the first 48 h of appropriate antibiotic treatment. There was variation in biomarker levels among participants with the same infection type, especially in participants with bacteremia, musculoskeletal infection and skin/soft tissue infection.
Utility of procalcitonin as a biomarker to follow every 24-48 h in non-critically ill children receiving antibiotic therapy for bacterial infections as an objective measure of clinical improvement is promising.
对于接受适当抗生素治疗的非重症急性细菌感染儿科患者，降钙素原的动力学情况尚无充分描述。
我们对一家三级儿童专科医院收治的因非重症急性细菌感染接受抗生素治疗的儿童进行了一项单中心前瞻性观察性试点研究，并在住院期间连续4天每天前瞻性测量降钙素原水平。
在该研究纳入的46名有降钙素原基线水平的儿童中，大多数患者的降钙素原动力学半衰期约为24小时。在适当抗生素治疗的前48小时内，降钙素原下降速度比C反应蛋白快。相同感染类型的参与者之间生物标志物水平存在差异，尤其是在菌血症、肌肉骨骼感染和皮肤/软组织感染的参与者中。
对于接受抗生素治疗细菌感染的非重症儿童，每24至48小时监测降钙素原作为临床改善客观指标的生物标志物，其应用前景良好。
