Cuomo V, Cagiano R, Renna G, De Salvia M A, Racagni G
Neuropharmacology. 1987 Jul;26(7A):701-5. doi: 10.1016/0028-3908(87)90230-9.
Early postnatal administration of SCH 23390 and sulpiride induced marked changes in the ultrasonic vocalization elicited by the removal of rat pups from their nest. In particular, SCH 23390 produced a significant increase in the length, as well as in the sound pressure level, of ultrasonic calls; moreover, a significant decrease in minimum and maximum frequency values was found in pups treated with this DA1-receptor antagonist. Sulpiride significantly reduced the rate of calling, as well as the pressure level of sounds, whereas it did not influence other parameters of the ultrasonic emission. These behavioural alterations seemed to be the consequence of an impaired functional maturation of the dopamine (DA) system; however, the different changes caused by SCH 23390 and sulpiride, respectively, suggest that DA1- and DA2-receptor populations could play a distinct role in the ultrasonic calling during early postnatal life.
出生后早期给予SCH 23390和舒必利会使将幼鼠从巢中取出时引发的超声发声产生显著变化。具体而言，SCH 23390使超声叫声的时长以及声压水平显著增加；此外，在用这种DA1受体拮抗剂处理的幼鼠中，发现其最低和最高频率值显著降低。舒必利显著降低了叫声频率以及声音的压力水平，而对超声发射的其他参数没有影响。这些行为改变似乎是多巴胺（DA）系统功能成熟受损的结果；然而，SCH 23390和舒必利分别引起的不同变化表明，DA1和DA2受体群体在出生后早期的超声发声中可能发挥不同的作用。
