Cagiano R, Sales G D, Renna G, Racagni G, Cuomo V
Life Sci. 1986 Apr 14;38(15):1417-23. doi: 10.1016/0024-3205(86)90475-3.
The effects of prolonged postnatal administration of haloperidol (H) on ultrasonic vocalization elicited by the removal of rat pups from their nest were investigated. The results show that the number of ultrasonic calls was significantly reduced by H exposure from the 8th until the 14th day after birth. Conversely, this neuroleptic significantly increased the duration of ultrasound from the 4th up to the 16th day of age. Moreover, changes in the frequency of calls were produced by early postnatal treatment with H. These alterations could be due to an impaired functional maturation of the dopaminergic system produced by neonatal exposure to H. Furthermore, the present data suggest that ultrasonic vocalization may be considered as an early sensitive indicator of subtle changes elicited by the postnatal treatment with a dopamine receptor blocking agent at dose levels below those associated with overt signs of neurotoxicity.
研究了产后长期给予氟哌啶醇（H）对将幼鼠从巢中取出所引发的超声发声的影响。结果显示，从出生后第8天到第14天，暴露于H会使超声叫声的数量显著减少。相反，这种抗精神病药物从出生后第4天到第16天显著增加了超声的持续时间。此外，出生后早期用H治疗会导致叫声频率发生变化。这些改变可能是由于新生儿接触H导致多巴胺能系统功能成熟受损所致。此外，目前的数据表明，超声发声可被视为产后用多巴胺受体阻断剂治疗在低于与明显神经毒性迹象相关剂量水平时所引发的细微变化的早期敏感指标。
