Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China.
Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China.
Hum Vaccin Immunother. 2021 Apr 3;17(4):1113-1121. doi: 10.1080/21645515.2020.1824497. Epub 2020 Oct 16.
A novel coronavirus (2019-nCov) emerged in China, at the end of December 2019 which posed an International Public Health Emergency, and later declared as a global pandemic by the World Health Organization (WHO). The International Committee on Taxonomy of Viruses (ICTV) named it SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2), while the disease was named COVID-19 (Coronavirus Disease- 2019). Many questions related to the exact mode of transmission, animal origins, and antiviral therapeutics are not clear yet. Nevertheless, it is required to urgently launch a new protocol to evaluate the side effects of unapproved vaccines and antiviral therapeutics to accelerate the clinical application of new drugs. In this review, we highlight the most salient characteristics and recent findings of COVID-19 disease, molecular virology, interspecies mechanisms, and health consequences related to this disease.
一种新型冠状病毒（2019-nCov）于 2019 年 12 月底在中国出现，构成国际公共卫生紧急事件，后被世界卫生组织（WHO）宣布为全球大流行。国际病毒分类委员会（ICTV）将其命名为 SARS-CoV-2（严重急性呼吸系统综合征冠状病毒-2），而该疾病被命名为 COVID-19（2019 年冠状病毒病）。许多与确切传播方式、动物起源和抗病毒治疗相关的问题仍不清楚。然而，迫切需要启动一项新方案来评估未经批准的疫苗和抗病毒治疗的副作用，以加速新药的临床应用。在这篇综述中，我们重点介绍了 COVID-19 疾病、分子病毒学、种间机制以及与该疾病相关的健康后果的最显著特征和最新发现。
