快照：抗疟药物。

SnapShot: Antimalarial Drugs.

机构信息

Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.

Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Skaggs School of Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.

出版信息

Cell. 2020 Oct 15;183(2):554-554.e1. doi: 10.1016/j.cell.2020.09.006.

DOI:10.1016/j.cell.2020.09.006

PMID:33064992

Abstract

Malaria is a prominent vector-borne illness caused by Plasmodium parasites. Therapeutic intervention remains a critical component for disease eradication efforts but is complicated by the emergence of drug resistance. This SnapShot summarizes the human-relevant stages of the P. falciparum life cycle and describes how licensed antimalarials, clinical candidates, and newly emerging compounds target each stage to prevent, treat, or block transmission of malaria. To view this SnapShot, open or download the PDF.

摘要

疟疾是一种由疟原虫引起的重要的虫媒传染病。治疗干预仍然是消除疾病努力的关键组成部分，但耐药性的出现使情况变得复杂。本 SnapShot 总结了恶性疟原虫生命周期中与人类相关的阶段，并描述了已许可的抗疟药物、临床候选药物和新出现的化合物如何针对每个阶段进行靶向，以预防、治疗或阻断疟疾的传播。要查看此 SnapShot，请打开或下载 PDF。